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CCT5 como biomarcador candidato en el cáncer de vejiga: validación funcional y pistas mecanicistas
Xiaojun Zhang1,2, Yuqiang Fu1,2, Yuelin Du1,2
1Department of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital of Lanzhou University Lanzhou 730030, Gansu, China.
American journal of cancer research
|February 9, 2026
Resumen
La subunidad 5 del complejo TCP1 que contiene chaperonina (CCT5) está regulada al alza en el cáncer de vejiga, promoviendo el crecimiento tumoral y la invasión. Su agotamiento activa la señalización Hippo / YAP, lo que sugiere que CCT5 es un objetivo terapéutico potencial.
Área de la Ciencia:
- Oncología Oncología.
- Biología Molecular Biología Molecular
- Genómica del cáncer Genómica del cáncer.
Sus antecedentes:
- La subunidad 5 del complejo TCP1 que contiene chaperonina (CCT5) está relacionada con varios tipos de cáncer.
- El papel específico de CCT5 en el cáncer de vejiga (BC) y sus mecanismos moleculares no se comprenden bien.
- La investigación de CCT5 en BC puede revelar nuevos objetivos terapéuticos.
Objetivo del estudio:
- Para investigar el papel funcional de CCT5 en el cáncer de vejiga.
- Explorar la asociación entre CCT5 y la señalización Hippo/YAP en BC.
- Evaluar CCT5 como un potencial biomarcador pronóstico y objetivo terapéutico para BC.
Principales métodos:
- Análisis de la expresión de CCT5 y el valor pronóstico utilizando conjuntos de datos TCGA y GEO.
- Transcriptómica unicelular y espacial para evaluar los patrones de expresión y la heterogeneidad celular.
- Ensayos funcionales in vitro e in vivo (xenoinjerto), secuenciación de ARN y Western blotting para elucidar los mecanismos.
Principales resultados:
- La CCT5 está significativamente regulada al alza en el cáncer de vejiga, lo que se correlaciona con un mal pronóstico y características agresivas.
- CCT5 se enriquece en células epiteliales malignas con altas puntuaciones de variación del número de copias (CNV) y vías oncogénicas activadas.
- CCT5 promueve la proliferación de células BC, la migración, la invasión y la progresión del ciclo celular, al tiempo que inhibe la apoptosis; el agotamiento de CCT5 reduce el crecimiento tumoral y activa la señalización Hippo / YAP.
Conclusiones:
- CCT5 actúa como un factor oncogénico en el cáncer de vejiga, impulsando la progresión tumoral.
- CCT5 puede ejercer sus efectos oncogénicos mediante la regulación de la señalización Hippo/YAP.
- CCT5 presenta un biomarcador prometedor y un objetivo terapéutico para el tratamiento del cáncer de vejiga.
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