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Desentrañar los efectos de la esterilización en el Konjac Glucomanano: Perspectivas sobre un biopolímero natural para
Mariah Zajankauskas Orçati1, Mariana Agostini de Moraes1, Marisa Masumi Beppu1
1School of Chemical Engineering, Department of Materials and Bioprocess Engineering, University of Campinas, Campinas, SP 13083-852, Brazil.
ACS omega
|February 9, 2026
Resumen
La esterilización de los biomateriales de konjac glucomanano (KGM) es crucial. La autoclave y el óxido de etileno (EtO) mejor preservaron la integridad de la película KGM, mientras que la irradiación gamma y UV causaron cambios significativos, destacando la necesidad de una cuidadosa selección del método de esterilización.
Área de la Ciencia:
- Ciencia de los Biomateriales Ciencia de los Biomateriales.
- Química de Polímeros La Química de Polímeros es la química de los polímeros.
- Ingeniería Biomédica Ingeniería Biomédica.
Sus antecedentes:
- La esterilización es fundamental para la seguridad y la biocompatibilidad de los materiales biomédicos.
- El glucomanano de Konjac (KGM) es un biopolímero prometedor para la curación de heridas y la ingeniería de tejidos debido a sus propiedades.
- La sensibilidad de los biomateriales a la esterilización requiere evaluar los impactos del método en la integridad.
Objetivo del estudio:
- Evaluar los efectos de varios métodos de esterilización y desinfección en las películas basadas en KGM.
- Evaluar la preservación de las propiedades físicas, químicas, mecánicas y biológicas de las películas KGM después de la esterilización.
Principales métodos:
- Las películas KGM fueron sometidas a autoclave, óxido de etileno (EtO), irradiación gamma (γ), radiación UV y 70% de etanol.
- Las evaluaciones incluyeron microscopía electrónica de barrido (SEM), FTIR, XRD, TGA, pruebas mecánicas y ensayos de citotoxicidad in vitro.
Principales resultados:
- La irradiación gamma (γ) y UV causó las alteraciones más significativas en las propiedades de la película KGM.
- Los métodos de autoclave y esterilización con óxido de etileno (EtO) mantuvieron mejor la integridad estructural y funcional de las películas KGM.
- El 70% de etanol demostró ser eficaz como desinfectante para las películas de KGM.
Conclusiones:
- La elección del método de esterilización tiene un impacto crítico en las propiedades y la eficacia de los biomateriales basados en KGM.
- Se recomienda el autoclave y el EtO para esterilizar las películas KGM para preservar su integridad.
- La investigación adicional debe centrarse en la optimización de los protocolos de esterilización para los biomateriales KGM en aplicaciones biomédicas.
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