Video Experimental Relacionado

Updated: Feb 11, 2026

Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid

Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid

Published on: December 4, 2017

Estudio de Caso-Control que Vincula las Concentraciones de Microplásticos en el Líquido Cefalorraquídeo Humano con el

Zebin Fang¹, Xiaoyi Wang¹, Fan Wu¹

¹Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, P. R. China.

Environmental pollution (Barking, Essex : 1987)

|February 9, 2026

Abstract:

Microplastics (MPs) have become a global concern due to their widespread environmental presence and human health risk, yet their risk on cerebrovascular diseases remains largely unexplored. In this case-control study, we collected cerebrospinal fluid samples from 48 intracranial aneurysms (IAs) patients and 108 leptomeningeal metastasis (LM) patients, and investigated the presence of MPs in these cerebrospinal fluid samples using pyrolysis-gas chromatography-mass spectrometry. Seven types of MPs were identified in the cerebrospinal fluid samples, among which polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), and polystyrene were present in over 80% of the samples. PE and PP were the most abundant MPs in cerebrospinal fluid samples. When using LM patients as controls, a significantly increased risk of IA was observed for subjects in the highest quartile of cerebrospinal fluid PP and PVC levels. Compared to the lowest quartile, the adjusted risk was elevated by 2.25-fold (95% CI: 1.68-5.94) and 3.82-fold (95% CI: 2.57-5.41) for PP and PVC levels, respectively. Our analysis revealed significant (p for trend < 0.01) dose-response relationships between cerebrospinal fluid MP mixture concentrations and IA risk. Bayesian kernel machine regression and quantile g-computation models further revealed synergistic effects of co-occurrence to MPs, with PVC contributing the strongest contribution (weight 55.8%). Our results suggest a potential link between higher cerebrospinal fluid levels of MPs and elevated IA risk, and highlight the need for further investigation into this emerging health risk.

Palabras clave:

Líquido cefalorraquídeo Riesgo de exposición Aneurismas intracraneales Microplásticos Pirólisis-GC/MS

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