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Relaciones entre plasticidad del material, fragilidad de la tableta y resistencia a la tracción
Ramy N Elsergany1, Changquan Calvin Sun1
1Pharmaceutical Materials Sciences and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, United States.
International journal of pharmaceutics
|February 9, 2026
Resumen
La resistencia mecánica de las tabletas depende de las propiedades del material y la compactación. Este estudio vincula la fragilidad de las tabletas y la plasticidad del polvo, lo que permite la predicción temprana de la resistencia de las tabletas y guía un diseño de tabletas robusto.
Área de la Ciencia:
- Ciencias Farmacéuticas
- Ciencias de los Materiales
- Ingeniería Química
Sus antecedentes:
- La resistencia mecánica de las tabletas es crucial para las formulaciones farmacéuticas.
- Está influenciada por las propiedades intrínsecas del material y los parámetros del proceso de compactación.
- Comprender estas relaciones es clave para un diseño robusto de tabletas.
Objetivo del estudio:
- Investigar las relaciones entre la resistencia a la tracción de la tableta, el índice de fragilidad de la tableta y la plasticidad del polvo (presión media de fluencia en troquel).
- Establecer modelos predictivos para las propiedades mecánicas de las tabletas basados en el comportamiento del polvo.
- Ofrecer un método eficiente para la orientación del desarrollo temprano de tabletas.
Principales métodos:
- Se seleccionaron siete excipientes comunes y doce mezclas binarias que representan diversos comportamientos mecánicos.
- Se caracterizó la resistencia a la tracción de la tableta y el índice de fragilidad en diferentes porosidades.
- Se cuantificó la plasticidad del polvo utilizando la presión media de fluencia en troquel a partir de datos de compresión.
Principales resultados:
- La resistencia y la fragilidad de las tabletas disminuyeron exponencialmente con el aumento de la porosidad para todos los materiales.
- Se encontró una correlación de ley de potencias entre la presión de fluencia media en troquel y el índice de fragilidad de la tableta a una porosidad fija.
- Esta correlación permite la predicción directa de la fragilidad de la tableta a partir de la presión de fluencia.
Conclusiones:
- La presión media de fluencia en troquel es un predictor eficaz de la fragilidad de la tableta.
- Este método proporciona una forma eficiente de estimar las propiedades mecánicas de las tabletas en las primeras etapas del desarrollo.
- Los hallazgos guían el diseño de tabletas robustas con la resistencia mecánica deseada.
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