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Linfoma cutáneo epitelotrópico con marcado pleomorfismo nuclear en un perro
Da-Hyeon Lee1, Woo-Jin Song2, Jongtae Cheong3
1College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea.
Journal of veterinary science
|February 9, 2026
Resumen
Este informe de caso detalla un linfoma cutáneo epitelotrópico canino (CEL) raro con características celulares inusuales que imitaron a otros cánceres. Se necesita más investigación para comprender esta presentación atípica del linfoma canino.
Área de la Ciencia:
- Patología Veterinaria; Oncología Canina; Dermatología
Sus antecedentes:
- El linfoma cutáneo epitelotrópico (CEL) es un cáncer raro en perros.; Las presentaciones atípicas, incluidas las formas celulares inusuales y los marcadores inmunes, se documentan con poca frecuencia.
Objetivo del estudio:
- Describir un caso raro de CEL canino con pleomorfismo celular significativo.; Destacar los desafíos diagnósticos que plantea la morfología atípica del CEL.
Principales métodos:
- Un Golden Retriever con lesiones orales y cutáneas se sometió a aspiración con aguja fina e histopatología.; Se utilizaron citometría de flujo y PCR para la reorganización del receptor de antígenos para la inmunofenotipificación y la evaluación de la clonalidad.
Principales resultados:
- La citología sugirió tumores de células redondas como linfoma o melanoma amelanótico.; La histopatología confirmó CEL; la citometría de flujo reveló un fenotipo de células T CD5+; la PCR mostró clonalidad del receptor de linfocitos T gamma delta.
Conclusiones:
- Este caso demuestra características clinicopatológicas atípicas en el CEL canino.; Los hallazgos subrayan la importancia de los diagnósticos avanzados para un diagnóstico preciso y la comprensión de la biología de la enfermedad.
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