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Ions and Ionic Charges03:27

Ions and Ionic Charges

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In ordinary chemical reactions, the nucleus — which contains the protons and neutrons of each atom and thus identifies the element — remains unchanged. Electrons, however, can be added to atoms by transfer from other atoms, lost by transfer to other atoms, or shared with other atoms. The transfer and sharing of electrons among atoms govern the chemistry of the elements. During the formation of some compounds, atoms gain or lose electrons to form electrically charged particles called...
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Ion Channels01:19

Ion Channels

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The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
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Common Ion Effect03:24

Common Ion Effect

47.0K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
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Precipitation of Ions03:11

Precipitation of Ions

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Predicting Precipitation
The equation that describes the equilibrium between solid calcium carbonate and its solvated ions is:
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Formation of Complex Ions03:45

Formation of Complex Ions

26.2K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
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Ions as Acids and Bases02:54

Ions as Acids and Bases

26.6K
Salts with Acidic Ions
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
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Video Experimental Relacionado

Updated: Feb 11, 2026

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
08:40

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

Published on: January 20, 2022

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Metabolómica unicelular de cobertura profunda habilitada por citometría de masas resuelta por movilidad iónica

Mingdu Luo1,2, Tianzhang Kou1,2, Yandong Yin1

  • 1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P. R. China.

Nature methods
|February 9, 2026
PubMed
Resumen

Los investigadores desarrollaron una nueva tecnología de metabolómica unicelular con mayor sensibilidad y cobertura. Este avance permite una visión más profunda del metabolismo celular y la heterogeneidad, mejorando los métodos existentes.

Palabras clave:
metabolómica unicelularcitometría de masasmovilidad iónicadetección de metabolitosheterogeneidad metabólica

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Área de la Ciencia:

  • Bioquímica
  • Química Analítica
  • Biología Celular

Sus antecedentes:

  • Los métodos actuales de metabolómica unicelular enfrentan limitaciones en sensibilidad, robustez y cobertura de metabolitos.
  • Existe la necesidad de tecnologías avanzadas para permitir un perfilado metabólico integral a nivel unicelular.

Objetivo del estudio:

  • Presentar una nueva tecnología de citometría de masas resuelta por movilidad iónica para el perfilado metabolómico unicelular multidimensional.
  • Mejorar la sensibilidad, la robustez y la cobertura de metabolitos en la metabolómica unicelular.

Principales métodos:

  • Integración de inyección unicelular de alto rendimiento con espectrometría de masas de movilidad iónica.
  • Implementación de acumulación selectiva de iones habilitada por movilidad iónica y amplificación basada en superposición celular.
  • Se utilizó una herramienta computacional, MetCell, para el análisis de datos.

Principales resultados:

  • Se logró una sensibilidad a nivel de atto-mol y un amplio rango dinámico para la detección de metabolitos dentro de células individuales.
  • Se detectaron más de 5.000 picos metabólicos y se anotaron aproximadamente 800 metabolitos por célula, lo que representa una mejora de 3 a 10 veces.
  • Se aplicó con éxito a 45.603 células hepáticas primarias, lo que permitió una anotación celular precisa y reveló la heterogeneidad metabólica en hepatocitos envejecidos.

Conclusiones:

  • La tecnología desarrollada establece un nuevo punto de referencia para la metabolómica unicelular de alto rendimiento.
  • Esta plataforma avanza significativamente la comprensión de la heterogeneidad metabólica a resolución unicelular.
  • Ofrece una herramienta poderosa para la investigación biológica que requiere una profunda visión metabólica.