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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Ribosomal RNA Synthesis02:53

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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
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Complejos ARN-hierro catalizan la generación de oxígeno prebiótico

Ying-Chi Wang1,2, Jing-Hong Tu1,2, Lung-Chih Yu1,2

  • 1Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan.

Communications chemistry
|February 9, 2026
PubMed
Resumen

Complejos antiguos de ARN-hierro catalizaron la descomposición del peróxido de hidrógeno en oxígeno y agua en las condiciones de la Tierra primitiva. Esta actividad redox del ARN precede a las enzimas proteicas, ofreciendo información sobre la vida temprana.

Palabras clave:
ARNhierroperóxido de hidrógenooxígenovida tempranacatálisisprebióticocomplejosredoxenzimas

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Área de la Ciencia:

  • Estudios del origen de la vida
  • Bioquímica
  • Astrobiología

Sus antecedentes:

  • La fotosíntesis oxigénica está relacionada con la aparición del oxígeno.
  • La vida temprana enfrentó desafíos para manejar especies reactivas de oxígeno como el peróxido de hidrógeno (H2O2).
  • Los procesos abióticos podrían generar H2O2 en la Tierra primitiva.

Objetivo del estudio:

  • Investigar el papel potencial del ARN en el manejo del estrés oxidativo de la Tierra primitiva.
  • Explorar la actividad catalítica de los complejos ARN-metal.
  • Proponer un mecanismo para la desintoxicación de H2O2 antes de las enzimas proteicas.

Principales métodos:

  • Se estudiaron complejos de ARN-hierro ferroso (Fe2+).
  • Se evaluó la oxidación catalítica de H2O2 en O2 y H2O.
  • Se simularon condiciones anóxicas de la Tierra primitiva.

Principales resultados:

  • Ciertas moléculas de ARN coordinadas con Fe2+ catalizan la oxidación de H2O2.
  • Esta reacción produce O2 y H2O en condiciones anóxicas.
  • Demostró actividad redox basada en ARN anterior a las enzimas proteicas.

Conclusiones:

  • Los complejos ARN-metal probablemente ayudaron a la desintoxicación de H2O2 y al manejo del estrés oxidativo.
  • Los complejos ARN-Fe ofrecen un vínculo molecular entre los oxidantes geoquímicos y la química redox biológica temprana.
  • Las funciones catalíticas del ARN pueden haber sido cruciales para la supervivencia de la vida temprana.