Video Experimental Relacionado
Updated: Feb 11, 2026
09:01
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
14.8K
La LncRNA AC098613.1 promueve la diferenciación de células de leucemia mieloide aguda a través del eje
Qingling Jiang1, Xiaoting Wang1, Hang Yao1
1Featured Laboratory for Biosynthesis and Target Discovery of Active Components of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Binzhou Medical University, Yantai, 264003, Shandong, China.
Apoptosis : an international journal on programmed cell death
|February 9, 2026
Resumen
El ARN largo no codificante AC098613.1 promueve la diferenciación de células de leucemia mieloide aguda (LMA). La sobreexpresión de esta lncRNA inhibe la proliferación y el crecimiento tumoral al regular proteínas clave, ofreciendo una nueva diana terapéutica para la LMA.
Área de la Ciencia:
- Biología Molecular; Oncología; Biología de ARN
Sus antecedentes:
- Los ARN largos no codificantes (lncRNAs) son cada vez más reconocidos por su papel en la leucemia.
- La terapia de diferenciación es una estrategia de tratamiento prometedora para la leucemia mieloide aguda (LMA).
- La investigación sobre lncRNAs en la terapia de diferenciación de LMA es limitada.
Objetivo del estudio:
- Investigar el papel de AC098613.1 en la diferenciación de células de leucemia mieloide aguda (LMA).
- Elucidar los mecanismos moleculares por los cuales AC098613.1 influye en el comportamiento de las células de LMA.
- Evaluar AC098613.1 como una posible diana terapéutica para la LMA.
Principales métodos:
- Análisis de la expresión de AC098613.1 en células THP-1 diferenciadas y pacientes con LMA.
- Sobreexpresión de AC098613.1 en líneas celulares THP-1 y HL-60.
- Investigación de dianas moleculares que incluyen CDC5L, ADAP1, NRD1 y CDK1.
- Estudios in vivo utilizando modelos animales para evaluar la inhibición del crecimiento tumoral.
Principales resultados:
- La expresión de AC098613.1 fue significativamente mayor en células THP-1 diferenciadas y menor en pacientes con LMA.
- La sobreexpresión de AC098613.1 inhibió la proliferación e indujo la diferenciación en líneas celulares de LMA.
- AC098613.1 mejoró la estabilidad de CDC5L, promovió la transcripción de ADAP1 y aumentó la expresión de NRD1.
- In vivo, la sobreexpresión de AC098613.1 inhibió el crecimiento tumoral al regular CDC5L, ADAP1, NRD1 y CDK1.
Conclusiones:
- AC098613.1 desempeña un papel crucial en la promoción de la diferenciación de células de LMA.
- El mecanismo implica la regulación del eje CDC5L/ADAP1/NRD1.
- AC098613.1 representa una diana terapéutica novedosa y prometedora para la terapia de diferenciación de LMA.
Videos de Conceptos Relacionados
02:39lncRNA - Long Non-coding RNAs
10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
02:39lncRNA - Long Non-coding RNAs
3.7K
3.7K
01:15Differentiation of Common Myeloid Progenitor Cells
4.0K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.0K
02:40The Eukaryotic Promoter Region
18.9K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences. The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.9K
01:37Hypothalamic-Pituitary Axis
66.5K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
66.5K
01:16Perpendicular-Axis Theorem
4.6K
The perpendicular-axis theorem states that the moment of inertia of a planar object about an axis perpendicular to its plane is equal to the sum of the moments of inertia about two mutually perpendicular concurrent axes lying in the plane of the body.
Consider a circular disc of mass M and radius R lying along an x-y plane. The origin lies at the center of the disc, and the z-axis is perpendicular to the disc's plane. All three axes coincide at the disc's center. The moment of inertia of this...
Consider a circular disc of mass M and radius R lying along an x-y plane. The origin lies at the center of the disc, and the z-axis is perpendicular to the disc's plane. All three axes coincide at the disc's center. The moment of inertia of this...
4.6K