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La impedancia de la mucosa esofágica a mitad del esófago refleja la integridad de la mucosa y los fenotipos de

Bo Li¹, Ye Chen¹, Ying Chen¹

¹Department of Gastroenterology, Tongji Institute of Digestive Disease, Tongji Hospital affiliated to Tongji University, Tongji University School of Medicine, Shanghai, China.

BMC gastroenterology

|February 9, 2026

Resumen

Las mediciones de impedancia a mitad del esófago pueden ayudar a identificar las causas subyacentes de los síntomas refractarios similares al reflujo (rRLS). Una impedancia más baja sugiere problemas estructurales, mientras que una impedancia más alta puede indicar acidez funcional o hipersensibilidad al reflujo.

Área de la Ciencia:

Gastroenterología; Fisiología Esofágica; Investigación de Enfermedades por Reflujo

Sus antecedentes:

Los síntomas refractarios similares al reflujo (rRLS) presentan desafíos diagnósticos debido a la variedad de mecanismos subyacentes.; La impedancia de la mucosa esofágica es un marcador de la integridad de la mucosa, pero su papel en la fenotipificación de rRLS no se comprende completamente.

Objetivo del estudio:

Investigar la utilidad de la impedancia de la mucosa esofágica en la fenotipificación de pacientes con rRLS.; Determinar si las mediciones de impedancia específicas de la ubicación pueden diferenciar entre subtipos de rRLS.

Principales métodos:

Estudio retrospectivo de pacientes adultos con síntomas similares al reflujo sometidos a monitorización de impedancia-pH y manometría.; Evaluación de la impedancia basal (BI) y la impedancia basal nocturna media (MNBI) a mitad del esófago en pacientes con rRLS.; Clasificación de pacientes con rRLS en ERGE refractaria, acidez funcional/hipersensibilidad al reflujo (FH/FES) o anomalías/funcionalidades estructurales esofágicas (ESFA).

Principales resultados:

La BI a mitad del esófago fue significativamente menor en pacientes refractarios en comparación con pacientes no refractarios.; La MNBI en el esófago medio difirió significativamente entre los fenotipos diagnósticos de rRLS.; La MNBI más baja se asoció con ESFA, mientras que la MNBI más alta fue más común en FH/FES.

Conclusiones:

La impedancia de la mucosa a mitad del esófago refleja la integridad de la mucosa y ayuda en la fenotipificación fisiológica de rRLS.; La evaluación de la impedancia específica de la ubicación puede complementar las pruebas convencionales para la clasificación basada en mecanismos.; La evaluación de la impedancia no debe usarse de forma aislada para guiar las decisiones de tratamiento.

Palabras clave:

Impedancia basal Impedancia basal nocturna media Síntomas similares al reflujo Refraccionario

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