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Un marco de red neuronal informado por la física para el análisis cuantitativo de la transcitosis y la difusión

Xin Wang¹, Bingyan Shen¹, Wenyuan Yang¹

¹School of Life Sciences, Henan University, Kaifeng City, 475000, Henan Province, China.

Journal of nanobiotechnology

|February 10, 2026

Resumen

Las nanopartículas cruzan la barrera hematoencefálica (BBB) a través de la difusión y la transcitosis. Un modelo de red neuronal informada por la física (PINN) reveló la absorción vesicular como la vía principal, con un aumento de la difusión durante la interrupción de la BBB.

Área de la Ciencia:

Ingeniería Biomédica Ingeniería Biomédica.
Nanotecnología La nanotecnología es la nanotecnología.
La neurociencia es la neurociencia.

Sus antecedentes:

La barrera hematoencefálica (BBB) restringe la entrada de nanopartículas en el cerebro.
La comprensión de los mecanismos de transporte de nanopartículas (difusión frente a la transcitosis vesicular) es crucial para la administración de fármacos.
La evaluación cuantitativa de estas vías sigue siendo un reto.

Objetivo del estudio:

Desarrollar un marco computacional para cuantificar las vías de transporte de nanopartículas a través de un modelo BBB humano in vitro.
Para diferenciar las contribuciones de la difusión pasiva y la transcitosis vesicular.
Para evaluar el comportamiento de las nanopartículas bajo diferentes condiciones de BBB.

Principales métodos:

Utilizó un modelo BBB humano in vitro (hCMEC / D3 Transwells).
Empleó una red neuronal informada por la física (PINN) integrada con datos experimentales.
Nanopartículas de poliestireno investigadas (20-120 nm) y intervenciones farmacológicas aplicadas (inhibidores del TNF-α, clatrina/dinamina).

Principales resultados:

PINN modeló con éxito la cinética de transporte de nanopartículas y las contribuciones de la vía.
La absorción vesicular fue identificada como la ruta de transporte dominante en condiciones normales.
La interrupción de las uniones estrechas y la inhibición de la endocitosis alteraron el equilibrio entre la difusión y el transporte vesicular.

Conclusiones:

El enfoque experimental-computacional combinado ofrece un método robusto para evaluar el transporte de nanopartículas BBB.
La transcitosis vesicular es la principal vía para las nanopartículas a través del BBB.
Este marco ayuda en el diseño de nanopartículas para la entrega dirigida al cerebro.

Palabras clave:

El modelo BBB in vitro es el modelo BBB.La difusión física es la difusión física.Las redes neuronales informadas por la física.La transcitosis es la transcitosis.

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