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Evaluación de los efectos protectores del selenio contra la toxicidad inducida por la sobrecarga de hierro en ratas
Ateeqah Ghayth Alzwawy1,2, Abdelhafidh Khazri3, Ahmed Kouki3
1Laboratory of Integrated Physiology LR17ES02, Faculty of Sciences of Bizerte, Carthage University, Jarzouna, Tunisia.
Resumen
La suplementación de selenio puede proteger contra la toxicidad por sobrecarga de hierro al reducir el estrés oxidativo y el daño a los órganos en ratas. Este estudio muestra selenio.
Área de la Ciencia:
- La bioquímica es la bioquímica.
- Toxicología Toxicología.
- Ciencias de la Nutrición Ciencias de la Nutrición
Sus antecedentes:
- La sobrecarga de hierro está relacionada con la generación de especies reactivas de oxígeno (ROS), el estrés oxidativo y las enfermedades.
- El selenio, un oligoelemento, exhibe propiedades antioxidantes y prooxidantes.
- Comprender la interacción entre el hierro y el selenio es crucial para manejar los problemas de salud relacionados.
Objetivo del estudio:
- Para investigar los efectos protectores del selenio contra la toxicidad inducida por la sobrecarga de hierro en ratas.
- Para explorar las interacciones bioquímicas entre el hierro y el selenio en varios órganos.
Principales métodos:
- A las ratas adultas Wistar se les administraron dosis crecientes de hierro (25-100 mg/kg de peso corporal) en dosis crecientes. Solo o junto con el selenio (0,5 mg/kg de peso corporal). En el caso de las personas que se encuentran en situación de exclusión social.
- Se realizaron análisis bioquímicos en tejidos del hígado, el bazo, los riñones y el páncreas.
- Se midieron los niveles de catalasa (CAT), glutatión (GSH), glutatión-S-transferasa (GST), malondialdehído (MDA) y acetilcolinesterasa (AChE).
Principales resultados:
- La administración de hierro por sí sola indujo significativamente el estrés oxidativo, alterando los marcadores bioquímicos de una manera dependiente de la dosis y los órganos.
- El selenio (0,5 mg/kg de peso corporal) se encuentra en demostradamente atenuó los efectos adversos del hierro, mitigando el daño oxidativo.
- Los cambios observados en los niveles de CAT, GSH, GST, MDA y AChE se normalizaron con el tratamiento con selenio.
Conclusiones:
- El selenio exhibe efectos protectores contra el estrés oxidativo inducido por la sobrecarga de hierro y la toxicidad de órganos.
- Estos hallazgos apoyan el papel potencial del selenio en las estrategias nutricionales y terapéuticas para los trastornos del metabolismo del hierro.
- Investigaciones adicionales pueden explorar la aplicación del selenio en el manejo de condiciones asociadas con la desregulación del hierro.
Palabras clave:
Sobrecarga de hierro por exceso de carga.Los biomarcadores también son biomarcadores.El estrés oxidativo es el estrés oxidativo.efectos protectores de los efectos protectores.El selenio es el selenio.Más Videos Relacionados
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