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Reducciones en el consumo de cigarrillos y cannabis durante un ensayo clínico aleatorizado para el trastorno por
Malia A Belnap1,2, Kaitlin R McManus2, Dylan E Kirsch2
1Neuroscience Interdepartmental Program, University of California, Los Angeles, 695 Charles E Young Dr S, Los Angeles, CA 90095, United States.
Alcohol and alcoholism (Oxford, Oxfordshire)
|February 10, 2026
Resumen
Las personas con trastorno por consumo de alcohol (AUD) redujeron el consumo de cigarrillos y cannabis durante un ensayo. Los cambios en estos comportamientos de consumo de sustancias se relacionaron con la reducción de bebidas por día de consumo (DPDD).
Área de la Ciencia:
- Medicina de la adicción Medicina de la adicción
- Psicología Clínica Psicología clínica.
- Psicofarmacología y psicofarmacología.
Sus antecedentes:
- El uso simultáneo de alcohol, tabaco y cannabis es frecuente en los Estados Unidos.
- Comprender el uso de sustancias que ocurren al mismo tiempo es crucial para el tratamiento del trastorno por consumo de alcohol (AUD).
Objetivo del estudio:
- Para analizar los patrones de consumo de cigarrillos y cannabis durante un ensayo controlado aleatorizado (ECA) para AUD.
- Para determinar si los cambios en el consumo de cigarrillos y cannabis se asociaron con reducciones en el consumo de alcohol.
Principales métodos:
- Análisis secundario de un ECA de 12 semanas en el que participaron 102 participantes con AUD.
- Se examinaron los cambios en el consumo de cigarrillos y cannabis durante el ensayo.
- Evaluó la asociación entre los cambios en el consumo de cigarrillos / cannabis y los resultados del consumo de alcohol (porcentaje de días de consumo excesivo de alcohol, bebidas por día de consumo).
Principales resultados:
- Los participantes redujeron significativamente el consumo de cigarrillos a lo largo del ensayo (P=.002).
- El consumo de cannabis disminuyó inicialmente (P=.006) y luego aumentó (P=.03).
- Los cambios en el consumo de cigarrillos y cannabis no se asociaron significativamente con un porcentaje reducido de días de consumo excesivo de alcohol, pero se asociaron con cambios en las bebidas por día de consumo (DPDD).
Conclusiones:
- Las personas con AUD pueden reducir el consumo de cigarrillos y cannabis al mismo tiempo, incluso sin intervención directa.
- Las reducciones observadas en el consumo de cigarrillos y cannabis se asociaron significativamente con una disminución de la DPDD.
- Destaca la importancia de evaluar el uso de sustancias concomitantes en el tratamiento de AUD y en ensayos clínicos.
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