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Implantes intravítreos para la administración de medicamentos: eficacia clínica, seguridad y perspectivas
Carolina Nunes da Silva1, Thomas Toshio Inoue1, Marina França Dias2
1Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Expert opinion on drug delivery
|February 10, 2026
Resumen
Los sistemas de administración de fármacos intravítreos de liberación sostenida (SRI) ofrecen un tratamiento mejorado para los trastornos crónicos de la retina al permitir la administración prolongada de fármacos. Se necesita más innovación para optimizar la seguridad, la eficacia y la fabricabilidad para obtener mejores resultados para los pacientes.
Área de la Ciencia:
- Oftalmología Oftalmología.
- Ciencia de los Biomateriales Ciencia de los Biomateriales.
- Farmacología Farmacología.
Sus antecedentes:
- Los trastornos crónicos de la retina causan pérdida de visión irreversible, lo que requiere frecuentes inyecciones intravítreas.
- Los tratamientos actuales como los agentes anti-VEGF y los corticosteroides tienen limitaciones que incluyen una alta carga de tratamiento y riesgos acumulativos.
- Los sistemas de administración intravítrea de fármacos de liberación sostenida (SRI) tienen como objetivo superar estas limitaciones prolongando la actividad terapéutica y mejorando la adherencia del paciente.
Objetivo del estudio:
- Revisar la evolución y el potencial clínico de las DDS intravítreas.
- Para discutir los avances en el diseño polimérico, hidrogeles, sistemas de formación in situ y DDS impresos en 3D.
- Examinar las barreras a la traducción clínica de las DDS intravítreas.
Principales métodos:
- Una búsqueda exhaustiva de la literatura de PubMed, Scopus, Web of Science, ClinicalTrials.gov, y repositorios regulatorios. también se puede encontrar.
- Revisión de los datos publicados hasta diciembre de 2025.
- Análisis de los DDS intravítreos no biodegradables y biodegradables.
Principales resultados:
- Los DDS intravítreos están avanzando en la farmacoterapia ocular con liberación prolongada y localizada de fármacos.
- Se están desarrollando varias tecnologías DDS, incluidos implantes y sistemas de formación in situ.
- Los principales desafíos de formulación, preclínicos y regulatorios afectan la traducción clínica.
Conclusiones:
- Los DDS intravítreos están listos para redefinir la farmacoterapia retiniana.
- Es crucial una mayor innovación en biomateriales, diseño de polímeros y esterilización.
- La integración de la medicina de precisión y los biomateriales avanzados conducirá a terapias de retina optimizadas y mínimamente invasivas.
Palabras clave:
Ocular Oculares Oculares Oculares Oculares Oculares Oculares Oculares OcularesEl polímero biodegradable es un polímero biodegradable.ensayos clínicos de ensayos clínicos de ensayos clínicos ensayos clínicos ensayos clínicos ensayos clínicos ensayos clínicos ensayos clínicos ensayos clínicos ensayos clínicoslos implantes de los implantes de los implantes.intravítreo intravítreo intravítreoliberación sostenida de sustancias.
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