Video Experimental Relacionado

Updated: Feb 11, 2026

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

El extracto de hojas de cola hispida atenúa la hepatoreno-hematotoxicidad inducida por el tetracloruro de carbono a

Njideka I Ani¹, Nnenna Ajagu², Kenneth O Okolo¹

¹Department of Pharmacology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani, Enugu State, Nigeria.

Environmental toxicology

|February 10, 2026

Resumen

El extracto de cola hispida protege contra el daño hepático, renal y sanguíneo inducido por el tetracloruro de carbono (CCl4) en ratas. Este estudio muestra MECH.

Área de la Ciencia:

Farmacología y Toxicología.
Química de Productos Naturales Química de Productos Naturales
La bioquímica es la bioquímica.

Sus antecedentes:

El tetracloruro de carbono (CCl4) es un inductor conocido de toxicidad sistémica, causando daños significativos en el hígado, los riñones y la sangre.
El estrés oxidativo es un mecanismo clave subyacente al daño de órganos inducido por CCl4.
Cola hispida es una planta utilizada etnomedicinalmente con propiedades antioxidantes reportadas.

Objetivo del estudio:

Investigar los efectos protectores del extracto metanólico de Cola hispida (MECH) contra la toxicidad sistémica inducida por CCl4 en ratas.
Evaluar el impacto de MECH en los biomarcadores del estrés oxidativo, la función hepática y renal y los parámetros hematológicos.
Para evaluar los cambios histopatológicos en los órganos después de la exposición a CCl4 y el tratamiento MECH.

Principales métodos:

Las ratas se dividieron en seis grupos, incluido el control, solo CCl4, y grupos co-tratados con diferentes dosis de MECH.
CCl4 se administró por vía intraperitoneal para inducir toxicidad.
Los efectos protectores se evaluaron a través de ensayos bioquímicos (función hepática / renal, marcadores de estrés oxidativo), análisis hematológico e histopatología.

Principales resultados:

La administración de CCl4 aumentó significativamente los marcadores de daño hepático y renal, el estrés oxidativo (MDA elevado) y los trastornos hematológicos.
La administración concomitante de MECH, dependiendo de la dosis, revirtió estas alteraciones inducidas por CCl4.
El tratamiento MECH restauró los niveles de enzimas antioxidantes (SOD, CAT, GSH, GPx) y redujo el daño tisular histopatológico.

Conclusiones:

El extracto metanólico de Cola hispida (MECH) demuestra efectos protectores significativos contra la toxicidad hepato-renal y hematológica inducida por CCl4 en ratas.
MECH ejerce su acción protectora principalmente a través de mecanismos antioxidantes y antiinflamatorios.
Estos hallazgos apoyan el uso etnofarmacológico de Cola hispida para el manejo de la toxicidad multiorgánica relacionada con el estrés oxidativo.

Palabras clave:

Cola fue supida.CCl4 también CCl4 actividad antioxidante de la actividad antioxidante.Parámetros hematológicos Parámetros hematológicos toxicidad hepático-renal.El estrés oxidativo es el estrés oxidativo.

Más Videos Relacionados

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques

Published on: August 23, 2024

Videos de Conceptos Relacionados

Transcription Attenuation in Prokaryotes

Transcription Attenuation in Prokaryotes

Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure. Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
There are several different mechanisms used to attenuate transcription. In ribosome mediated...

The Carbon Cycle

The Carbon Cycle

Carbon is the basis of all organic matter on Earth, and is recycled through the ecosystem in two primary processes: one in which carbon is exchanged among living organisms, and one in which carbon is cycled over long periods of time through fossilized organic remains, weathering of rocks, and volcanic activity. Human activities, including increased agricultural practices and the burning of fossil fuels, has greatly affected the balance of the natural carbon cycle.

Carbon Skeletons

Carbon Skeletons

Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side...

Carbonation Shrinkage

Carbonation Shrinkage

Atmospheric CO2 penetrates the concrete's pores and, in the presence of moisture, forms carbonic acid, which then reacts with calcium hydroxide in the hydrated cement, forming calcium carbonate. This process reduces the concrete's volume and is termed carbonation shrinkage.
The concrete's permeability is slightly reduced as calcium carbonate produced during the reaction fills its pores. Furthermore, its strength is slightly enhanced as the water released during the reaction...

Carbon-dioxide Fixation

Carbon-dioxide Fixation

Carbon dioxide fixation in prokaryotes enables the assimilation of inorganic carbon into organic molecules, supporting biosynthetic pathways, sustaining ecosystems, and contributing to the global carbon cycle. It also has industrial applications in carbon capture and bioproduct synthesis. Autotrophic organisms rely on this process to utilize CO₂ as a carbon source in diverse environments.The Calvin CycleThe Calvin cycle is the most widespread carbon fixation mechanism, primarily used by...

Carbon-13 (¹³C) NMR: Overview

Carbon-13 (¹³C) NMR: Overview

Carbon-13 is a naturally occurring NMR-active isotope of carbon with a low natural abundance of 1.1%. In contrast, carbon-12 is the most abundant isotope of carbon with zero nuclear spin. Therefore, it is NMR inactive. The gyromagnetic ratio of carbon-13 is smaller than that of protons. As a result, carbon-13 resonance is about 6000 times weaker than proton resonance. For a given magnetic field strength, the resonance frequency of carbon-13 is about one-fourth of the resonance frequency for...