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Asociación entre los polimorfismos del promotor de la interleucina-6 y la osteoporosis en mujeres javanesas

Sri Lestari Utami¹, Mohammad Hidayat², Diana Lyrawati³

¹Doctoral Program of Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia, Department of Biomedical, Medical Faculty, Universitas Wijaya Kusuma Surabaya, Surabaya, 60225, Indonesia.

European cytokine network

|February 10, 2026

Resumen

Se identificaron polimorfismos promotores de genes de la interleucina-6 (IL-6) en mujeres javanesas posmenopáusicas. Sin embargo, estas variaciones genéticas no se correlacionaron con la expresión de IL-6 o el estado de la osteoporosis en esta población.

Área de la Ciencia:

Genética La genética.
Investigación de la osteoporosis Investigación de la osteoporosis.
Biología Molecular Biología Molecular

Sus antecedentes:

La interleucina-6 (IL-6) juega un papel en el metabolismo óseo y la inflamación.
Los polimorfismos promotores del gen IL-6 se estudian por su asociación con diversas enfermedades.
El panorama genético de la IL-6 en las mujeres postmenopáusicas javanesas con respecto a la osteoporosis es en gran medida desconocido.

Objetivo del estudio:

Para investigar los polimorfismos del promotor IL-6 (-174G/C, -572G/C, -597A/G, -634C/G) en mujeres javanesas después de la menopausia.
Para determinar la asociación entre estos polimorfismos de IL-6 y el estado de la osteoporosis.
Para analizar la correlación de los polimorfismos de IL-6 con la expresión génica de IL-6 y los niveles de proteínas.

Principales métodos:

Estudio transversal en el que participaron 66 mujeres posmenopáusicas en Sidoarjo, Indonesia.
Densidad mineral ósea evaluada mediante absorptiometría de rayos X de doble energía (DXA).
Polimorfismos promotores de IL-6 genotipados por secuenciación de ADN; expresión génica por RT-PCR; niveles de proteínas por ELISA.

Principales resultados:

La osteoporosis y la osteopenia fueron prevalentes (28,8% y 57,6% respectivamente).
Se determinaron las frecuencias de los genotipos promotores de IL-6 para cada polimorfismo.
No se observaron diferencias estadísticamente significativas en los niveles de ARNm o proteínas de IL-6 en diferentes genotipos o estados de osteoporosis.

Conclusiones:

Los polimorfismos del promotor IL-6 existen en las mujeres javanesas posmenopáusicas.
Estos polimorfismos no están asociados con los niveles de expresión de ARNm o proteínas de IL-6.
No se encontró una correlación significativa entre los polimorfismos del promotor de IL-6 y el estado de la osteoporosis en esta cohorte.

Palabras clave:

Promotor del gen IL-6 promotor del gen IL-6.El javanés es javanés.La interleucina-6 también está presente.La osteoporosis es la osteoporosis.El polimorfismo es el polimorfismo.Después de la menopausia, la postmenopausia.

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