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LYSC98 como un nuevo agente derivado de la vancomicina eficaz contra los patógenos resistentes a los antibióticos en

Xing Xia^1,2, Mei Ge³, Junsheng Chen¹

¹School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.

The Journal of antimicrobial chemotherapy

|February 10, 2026

Resumen

LYSC98 mata eficazmente las bacterias resistentes a los antibióticos, incluidas las cepas tolerantes, al atacar las paredes y membranas celulares. Este nuevo fármaco muestra un bajo potencial de resistencia y es seguro para las células de mamíferos, ofreciendo esperanza para infecciones difíciles.

Área de la Ciencia:

Microbiología Microbiología.
Farmacología Farmacología.
Enfermedades infecciosas Enfermedades infecciosas.

Sus antecedentes:

La resistencia y la tolerancia a los antibióticos presentan desafíos clínicos significativos.
La tolerancia bacteriana puede acelerar la evolución de la resistencia a los antibióticos.
LYSC98 es un medicamento recientemente aprobado con actividad reportada contra el Staphylococcus aureus resistente, pero se desconoce su mecanismo contra las bacterias tolerantes.

Objetivo del estudio:

Evaluar la actividad antibacteriana de LYSC98 contra las bacterias resistentes a los antibióticos en varios estados metabólicos.
Para investigar el mecanismo de acción de LYSC98.

Principales métodos:

Determinación de la Concentración Mínima Inhibidora (MIC) a través de la microdilución del caldo.
Pruebas para matar el tiempo para evaluar los efectos bactericidas.
Microscopía electrónica de barrido (SEM) y microscopía electrónica de transmisión (TEM) para el análisis morfológico.
Prueba de yoduro de propidio para la evaluación de la permeabilidad de la membrana.

Principales resultados:

LYSC98 exhibe una potente actividad contra los patógenos Gram-positivos (MICs 0.062 mg/L).
Mata rápidamente las bacterias resistentes a los antibióticos, incluidos los estados tolerantes, y tiene un efecto post-antibiótico prolongado.
LYSC98 demuestra un bajo potencial para el desarrollo de resistencia y daña selectivamente las paredes y membranas celulares bacterianas sin dañar las células de los mamíferos.

Conclusiones:

LYSC98 muestra una rápida acción bactericida contra las bacterias resistentes y tolerantes.
Su mecanismo implica la interrupción selectiva de las paredes y membranas celulares bacterianas.
LYSC98 es un candidato prometedor para el tratamiento de infecciones crónicas y recalcitrantes debido a su eficacia, seguridad y bajo potencial de resistencia.

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