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El microbioma urinario y el metaboloma diferencian la vejiga hiperactiva del estado fisiológico, y reflejan el uso
Glenn T Werneburg1,2, Michael D Gross1, Daniel R Hettel1
1Department of Urology, Glickman Urological Institute, Cleveland Clinic, Cleveland, OH, USA.
The Journal of urology
|February 10, 2026
Resumen
El microbioma urinario difiere entre los individuos con y sin vejiga hiperactiva (OAB). Los géneros bacterianos específicos como Escherichia y Enterococcus son más abundantes en pacientes con OAB, lo que informa sobre posibles terapias dirigidas al microbioma.
Área de la Ciencia:
- Urología Urología Urología.
- La investigación del microbioma en la investigación del microbioma.
- La Metabolomía es una parte de la Metabolomía.
Sus antecedentes:
- El papel del microbioma urinario en la salud y la enfermedad es cada vez más reconocido.
- La vejiga hiperactiva (OAB) es una condición que afecta a millones de personas, con su fisiopatología subyacente que no se entiende completamente.
- La caracterización del microbioma urinario en la OAB puede revelar nuevos objetivos diagnósticos o terapéuticos.
Objetivo del estudio:
- Para comparar la composición del microbioma urinario bacteriano en individuos con y sin OAB.
- Investigar cómo la composición del microbioma urinario varía con el fenotipo de la OAB, las comorbilidades, la exposición a antibióticos y la respuesta al tratamiento.
Principales métodos:
- Se analizaron muestras de orina de mujeres con y sin OAB.
- Los perfiles bacterianos se determinaron mediante la secuenciación del ARNr 16S.
- Se generaron perfiles de metabolito a través de metabolomicas no dirigidas, y se mapearon las interacciones microbio-metabolito.
Principales resultados:
- Se observaron diferencias significativas en la composición del microbioma urinario entre los individuos con y sin OAB.
- Los géneros como *Escherichia*, *Enterococcus* y *Proteus* fueron más abundantes en individuos con OAB.
- *Megasphaera* y *Scardovia* fueron más abundantes en individuos sin OAB.
- La composición del microbioma también varió según el fenotipo OAB, el estado de la diabetes, el historial de antibióticos y la respuesta al tratamiento.
Conclusiones:
- Este estudio aclara los distintos perfiles del microbioma urinario asociados con la OAB.
- Los hallazgos destacan la influencia de las características del paciente y el tratamiento en la microbiota urinaria.
- Los resultados apoyan el desarrollo de estrategias de modulación del microbioma para complementar los tratamientos actuales de OAB.
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