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Afzelin resiste el daño de los rayos UVA a través de la autofagia y sinergiza con el ácido ganodérico A para el

Jia-Hua Zou¹, Mei-Ling Tai², Bao-Ying Li³

¹State Key Laboratory of Bioactive Molecules and Druggability Assessment & College of Pharmacy, Jinan University, Guangzhou, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|February 10, 2026

Resumen

Afzelin, un compuesto natural, combate el envejecimiento de la piel inducido por los rayos UVA mediante la activación de la autofagia y la mitofagia. Muestra efectos antienvejecimiento sinérgicos cuando se combina con ácido ganodérico A (GAA), ofreciendo potencial para el rejuvenecimiento de la piel.

Área de la Ciencia:

Dermatología Dermatología dermatología.
Biología celular Biología celular.
La bioquímica es la bioquímica.

Sus antecedentes:

La exposición crónica al ultravioleta A (UVA) acelera el envejecimiento de la piel a través del estrés oxidativo y la disfunción mitocondrial.
La disminución de la autofagia contribuye al envejecimiento de la piel, mientras que su papel en la fotoprotección necesita más estudios.
La afzelina, un flavonoide, posee propiedades antioxidantes, pero sus efectos fotoprotectores relacionados con la autofagia no se comprenden completamente.

Objetivo del estudio:

Investigar los efectos protectores de la afzelina contra el fotoenvejecimiento inducido por UVA a través de la autofagia y la activación de la mitofagia.
Evaluar el potencial sinérgico antienvejecimiento de la afzelina combinada con ácido ganodérico A (GAA).

Principales métodos:

Los fibroblastos dérmicos humanos fueron sometidos a irradiación UVA y a senescencia inducida por D-galactosa.
Se utilizó el Western blotting, la inmunofluorescencia y la citometría de flujo para analizar los cambios celulares.
Un modelo de ratón UVA de 20 días evaluó la eficacia de la aplicación tópica, con una sinergia cuantificada utilizando el modelo Bliss.

Principales resultados:

Afzelin mejoró la viabilidad celular, redujo los marcadores de senescencia (β-galactosidasa, p53, p21) y restauró la Lamin B1.
Disminuyó las especies reactivas de oxígeno (ROS) y aumentó el potencial de la membrana mitocondrial a través de las vías AMPK-AKT/mTOR-ULK1 y PINK1-Parkin.
Afzelin y GAA mostraron una sinergia significativa (Bliss = 67.6 ± 5.1), reduciendo el grosor epidérmico y mejorando la estructura de la piel in vivo.

Conclusiones:

Afzelin alivia efectivamente el fotodamago inducido por los rayos UVA al activar la autofagia y la mitofagia.
Afzelin demuestra efectos anti-fotoenvejecimiento sinérgicos con GAA, un conocido triterpenoide anti-envejecimiento.
Afzelin se muestra prometedor como un agente natural dirigido a la autofagia para el rejuvenecimiento de la piel.

Palabras clave:

Afzelin también es conocido como Afzelin.La autofagia es la autofagia.El ácido ganodérico A.La mitofagia es la mitofagia.El fotoenvejecimiento.El UVA es UVA.

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