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Atograma por mililitro de detección de biomarcadores de cáncer de próstata utilizando transistores orgánicos de

Samira Mansouri Majd¹, Fatemeh Mirzapour², Mojtaba Shamsipur²

¹Department of Semiconductors, Materials and Energy Research Center (MERC), P.O. Box, Karaj, 31787-316, Iran.

Biosensors & bioelectronics

|February 10, 2026

Resumen

Este estudio desarrolló un nuevo sensor semiconductor de polímero punto (Pdot) para la detección ultrasensible de biomarcadores de cáncer de próstata. El inmunosensor Pdot con transistor orgánico de efecto de campo (EGOFET) conectado a electrolitos logró un límite bajo de detección para el antígeno PSA.

Área de la Ciencia:

Ciencias de los materiales: Síntesis de nuevos puntos de polímero semiconductor (Pdots).
Biotecnología: Desarrollo de un inmunosensor para la detección de biomarcadores.

Sus antecedentes:

La detección temprana de los biomarcadores del cáncer de próstata es crucial para el diagnóstico y el pronóstico.
El antígeno prostático específico (PSA) es un biomarcador clave para el cáncer de próstata.

Objetivo del estudio:

Para sintetizar nuevos Pdots para su uso en transistores orgánicos de efecto de campo (EGOFETs) con entrada de electrolitos.
Desarrollar un inmunosensor EGOFET ultrasensible para la detección del antígeno PSA.

Principales métodos:

Fabricación de Pdot EGOFETs por goteo de Pdots y funcionalización con anticuerpos de PSA.
Prueba del rango de detección, sensibilidad y límite de detección (LOD) del sensor para el antígeno PSA.
Evaluación de las características eléctricas (movilidad, relación encendido/apagado, SS) y la selectividad en comparación con ELISA.

Principales resultados:

El inmunosensor Pdot EGOFET detectó el antígeno del PSA de 10 ag/mL a 10 ng/mL con una alta sensibilidad (0.9097 μA/década) y un LOD de 3.0 ag/mL.
Se lograron excelentes propiedades eléctricas: movilidad (0,029 cm2V-1s-1), relación encendido/apagado (22,66) y SS (909,1 mV/década).
Se ha demostrado una selectividad superior en comparación con ELISA en muestras de suero humano.

Conclusiones:

El inmunosensor Pdot EGOFET desarrollado muestra un potencial significativo para el diagnóstico ultrasensible del cáncer de próstata.
Esta plataforma ofrece un método altamente efectivo para el diagnóstico del cáncer y el monitoreo terapéutico.
La tecnología EGOFET basada en Pdot avanza en las capacidades de biosensores para la detección temprana de enfermedades.

Palabras clave:

Transistores orgánicos de efecto de campo con compuertas de electrolitos.El sensor inmunológico es un sensor inmunológico.La PSMA también se encargará de la PSMA.El cáncer de próstata es un cáncer de próstata.El antígeno específico de próstata.Polímero semiconductor punto por punto.

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