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Resultados de la radiocirugía con cuchillo gamma para los meningiomas que cubren la corteza motora
Neil D Almeida1, Shefalika Prasad2, Venkatesh Madhugiri1
1Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA; Department of Radiation Oncology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Resumen
La radiocirugía Gamma Knife (GKRS) controla eficazmente los meningiomas de la corteza motora, especialmente los tumores pequeños y de bajo grado. Este tratamiento ofrece una opción segura para esta región crítica del cerebro con una cuidadosa selección del paciente.
Área de la Ciencia:
- La neurocirugía es la neurocirugía.
- Radioncología Oncología de Radiación.
- Oncología Oncología.
Sus antecedentes:
- Los meningiomas de la corteza motora presentan desafíos de tratamiento debido al daño neurológico potencial.
- La radiocirugía Gamma Knife (GKRS) se evalúa por su eficacia en el manejo de estos tumores.
Objetivo del estudio:
- Para evaluar los resultados clínicos, de imagen y de supervivencia de los pacientes con meningiomas de la corteza motora tratados con GKRS.
- Para determinar los factores que influyen en el control del tumor y la supervivencia libre de progresión.
Principales métodos:
- Análisis retrospectivo de datos clínicos, de imágenes y de supervivencia de un registro institucional.
- Revisión de resonancia magnética en serie para los volúmenes de tratamiento y evaluación de la respuesta tumoral.
- La supervivencia libre de progresión y el control del tumor se analizaron utilizando métodos estándar de supervivencia.
Principales resultados:
- 47 pacientes con 58 meningiomas de la corteza motora fueron tratados con GKRS (anterior o adyuvante).
- Los meningiomas de grado 1 de la OMS y los volúmenes de tratamiento más pequeños (<5 cc) mostraron una supervivencia libre de progresión significativamente más larga.
- El grado de meningioma y el volumen de tratamiento se asociaron significativamente con el control del tumor.
Conclusiones:
- El GKRS demuestra un control eficaz del tumor para los meningiomas de la corteza motora.
- El tratamiento es particularmente beneficioso para pequeñas lesiones de Grado 1 de la OMS.
- El GKRS es una opción segura y eficaz para esta ubicación elocuente con una cuidadosa selección de pacientes y planificación de dosis.
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