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MYB: Un objetivo terapéutico potencial en el cáncer de mama triple negativo basado en la vía de señalización PI3K /
Ziyu Zhuang1, Jiayi Hu1, Hongbo Yu1
1School of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang 154007, China.
Computational biology and chemistry
|February 10, 2026
Resumen
El cáncer de mama triple negativo (TNBC) tiene un pronóstico peor que el no TNBC, vinculado a la vía PI3K/AKT. El gen MYB dentro de esta vía es un objetivo terapéutico potencial para el TNBC.
Área de la Ciencia:
- Oncología Oncología.
- La genómica es la genómica.
- La bioinformática es la bioinformática.
Sus antecedentes:
- El cáncer de mama triple negativo (TNBC) presenta un pronóstico significativamente peor en comparación con el cáncer de mama no triple negativo (No-TNBC).
- La vía PI3K/AKT es reconocida por su asociación con el pronóstico del cáncer de mama.
- El papel específico de la vía PI3K / AKT en las diferencias de pronóstico entre TNBC y no TNBC sigue siendo en gran medida inexplorado.
Objetivo del estudio:
- Para investigar los genes clave que impulsan el mal pronóstico en TNBC.
- Para aclarar el papel de la vía PI3K / AKT en la disparidad de pronóstico entre TNBC y no TNBC.
- Para identificar posibles dianas terapéuticas para el TNBC.
Principales métodos:
- Análisis integrado de conjuntos de datos transcriptómicos de la base de datos GEO.
- Aplicación de enriquecimiento funcional, aprendizaje automático, perfiles de infiltración de células inmunes, detección de sensibilidad a fármacos, secuenciación de ARN de una sola célula y transcriptómica espacial.
- Simulaciones de acoplamiento molecular para evaluar la afinidad de unión de MYB con compuestos de la Decocción Taohong Siwu.
Principales resultados:
- MYB fue identificado como el gen más crítico que distingue a TNBC de No-TNBC a través de 113 combinaciones de algoritmos.
- Un modelo de pronóstico confirmó una asociación significativa entre la expresión de MYB y los resultados de los pacientes.
- Los análisis multi-ómicos revelaron mecanismos de influencia de MYB en el pronóstico, incluida la infiltración de células inmunes y la sensibilidad a los medicamentos.
- El acoplamiento molecular mostró una fuerte unión entre los componentes de la Decocción Taohong Siwu y MYB.
Conclusiones:
- La vía PI3K/AKT es un factor clave que contribuye a las diferencias de pronóstico entre TNBC y no TNBC.
- El gen MYB, dentro de la vía PI3K / AKT, es un objetivo terapéutico potencial para el TNBC.
- Estos hallazgos ofrecen una base para el desarrollo de nuevas terapias dirigidas a MYB para pacientes con CNT.
Palabras clave:
Aprendizaje automático de aprendizaje automático.La vía de señalización PI3K/AKT.El pronóstico de la prognosis.Secuenciación de una sola célula.El transcriptoma espacial es el transcriptoma espacial.El cáncer de mama triple negativo.Más Videos Relacionados
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