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Las nanopartículas de óxido de cobre optimizadas Box-Behnken de Thymus vulgaris potencian la eficacia contra
Samah H Abu-Hussien1, Akebe Luther King2,3, Muhammad A Khan4
1Department of Agricultural Microbiology, Faculty of Agriculture, Ain Shams University, Cairo, 11241, Egypt. samah_hashem1@agr.asu.edu.eg.
Bioresources and bioprocessing
|February 10, 2026
Resumen
Las nanopartículas de óxido de cobre sintetizadas en verde de Thymus vulgaris muestran potentes efectos antimicrobianos y anticancerígenos. Estas nanopartículas derivadas de plantas exhiben actividad sinérgica con la gentamicina, ofreciendo una plataforma prometedora para combatir las infecciones resistentes a los medicamentos y el cáncer.
Área de la Ciencia:
- La nanomedicina y el descubrimiento de fármacos.
- Fitoquímica y productos naturales.
- Terapéutica antimicrobiana y anticancerígena Terapéutica antimicrobiana y anticancerígena.
Sus antecedentes:
- La resistencia a los antimicrobianos y el cáncer son desafíos urgentes para la salud mundial que requieren nuevas estrategias terapéuticas.
- Los tratamientos convencionales se enfrentan a limitaciones, lo que requiere plataformas innovadoras como las nanopartículas mediadas por plantas.
- El timo vulgar posee ricos fitoquímicos con potenciales aplicaciones terapéuticas.
Objetivo del estudio:
- Para sintetizar en verde las nanopartículas de óxido de cobre (TE-CuONPs) utilizando extracto de Thymus vulgaris.
- Para optimizar el proceso de síntesis utilizando el diseño de Box-Behnken para la producción de nanopartículas reproducibles.
- Evaluar las actividades antimicrobianas y anticancerígenas sinérgicas de los TE-CuONP sintetizados.
Principales métodos:
- El análisis HPLC identificó fitoquímicos clave (quercetina, ácido clorogénico, ácido gálico) en el extracto de Thymus vulgaris.
- La optimización de Box-Behnken determinó los parámetros críticos de síntesis (concentración de acetato de cobre, tiempo de incubación).
- La caracterización incluyó TEM, XRD, FTIR y DLS; se realizaron ensayos antimicrobianos (MIC, MBC, inhibición del biofilm, cinética de matanza del tiempo) y ensayos anticancerígenos (antiproliferativos, inducción de la apoptosis).
Principales resultados:
- Los TE-CuONP optimizados fueron de monodispersión, esféricos (19-25 nm) y cristalinos (fase CuO monoclínica).
- TE-CuONPs demostró una actividad bactericida significativa contra las bacterias Gram-positivas y Gram-negativas e inhibió la formación de biofilms.
- Se observaron efectos sinérgicos con la gentamicina, reduciendo las dosis requeridas y acelerando la erradicación bacteriana.
- TE-CuONPs exhibió una actividad antiproliferativa moderada contra las células de cáncer de mama MCF-7, induciendo la apoptosis.
- La capacidad antioxidante fue significativamente mayor que la del extracto vegetal crudo.
Conclusiones:
- Se puede lograr una síntesis verde reproducible de nanopartículas de óxido de cobre de Thymus vulgaris.
- Los TE-CuONP poseen un potencial antimicrobiano y anticancerígeno sinérgico significativo.
- Este estudio pone de relieve la promesa de traducción de la nanomedicina mediada por plantas para las enfermedades infecciosas y la terapia del cáncer.
Palabras clave:
La resistencia a los antibióticos es la resistencia a los antibióticos.La sinergia antimicrobiana es una sinergia antimicrobiana.Box-Behnken es la optimización de la optimización.Las nanopartículas de óxido de cobre.La nanotecnología verde es la nanotecnología verde.Más Videos Relacionados
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