Video Experimental Relacionado
Updated: Feb 12, 2026
09:09
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
2.3K
Tratamiento dirigido en enfermedades inflamatorias intestinales: lecciones de la detección en un ensayo clínico
Jason K Hou1,2, Jasmine Nguyen3, Jorge Rodriguez-Gaytan2
1Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, United States.
Crohn's & colitis 360
|February 11, 2026
Resumen
En la enfermedad inflamatoria intestinal (EII), muchos pacientes logran alivio de los síntomas, pero no la remisión endoscópica. La mayoría de los pacientes prefieren continuar con su terapia avanzada actual en lugar de cambiar, incluso cuando no se logra la curación endoscópica.
Área de la Ciencia:
- Gastroenterología y Gastroenterología.
- Los ensayos clínicos son ensayos clínicos.
- Enfermedades Inflamatorias del Intestino Investigación de la Enfermedad del Intestino.
Sus antecedentes:
- El tratamiento hasta el objetivo (TTT) en la enfermedad inflamatoria intestinal (EII) tiene como objetivo la remisión clínica y endoscópica.
- La remisión sintomática no siempre equivale a la curación endoscópica en pacientes con EII en terapias avanzadas.
- Los datos del mundo real sobre la discordancia y las preferencias de los pacientes para el manejo de la terapia avanzada son limitados.
Objetivo del estudio:
- Para determinar la prevalencia en el mundo real de la discordancia sintomática y endoscópica en la EII.
- Evaluar las preferencias del paciente y del proveedor con respecto a continuar o cambiar la terapia avanzada en EII.
- Para evaluar la aceptación del paciente de los ajustes de terapia avanzada cuando no se logra la remisión endoscópica.
Principales métodos:
- El ensayo QUOTIENT realizó ejercicios de cribado para estimar la prevalencia de la discordancia.
- Se utilizaron registros detallados de detección para evaluar a los pacientes con EII elegibles.
- Se registró la voluntad de participación y las preferencias del paciente y del proveedor.
Principales resultados:
- De 761 pacientes examinados con EII, el 12% en terapia avanzada y en remisión sintomática tenía inflamación endoscópica de moderada a grave.
- La razón principal para la disminución de la participación en el ensayo fue la preferencia del paciente por permanecer en la terapia avanzada actual (39%).
- Sólo el 11% declinó la participación debido a una preferencia por cambiar de terapia avanzada.
Conclusiones:
- Las tasas de remisión endoscópica en el mundo real en pacientes con EII son más altas de lo que sugieren los ensayos clínicos.
- Existe una preferencia significativa de los pacientes para mantener la terapia avanzada actual, en contraste con los objetivos de TTT del proveedor.
- Las preferencias del paciente juegan un papel crucial en las decisiones de manejo de la terapia avanzada para la EII.
Palabras clave:
La enfermedad de Crohn es la enfermedad de Crohn.enfermedad inflamatoria del intestino enfermedad inflamatoria del intestino.preferencias del paciente.ensayo clínico pragmático de ensayo clínico.preferencias del proveedor preferencias del proveedor.La colitis ulcerosa también se conoce como colitis ulcerosa.Más Videos Relacionados
Videos de Conceptos Relacionados
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.2K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.2K
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
1.1K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.1K
01:21Inflammatory Bowel Disease V: Surgical Management
639
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
639
01:29Inflammatory Bowel Disease IV: Pharmacological Management
718
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
718
01:16Clinical Trials
10.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.9K
01:11Clinical Trials: Overview
5.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K