Informe de caso: Un caso de leucemia de mastocitos tratado con avapritinib: desde el desafío diagnóstico hasta el trasplante
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Danilo Giuseppe Faraci1,2, Daniela Caravelli1,2, Fabrizio Carnevale Schianca1,2
1Medical Oncology, Hematopoietic Stem Cells Unit, Turin Metropolitan Transplant Center, Candiolo Cancer Institute, (FPO-IRCCS), Turin, Italy.
Frontiers in oncology
|February 11, 2026
Resumen
La leucemia de células de mastocitos (MCL) es un cáncer de sangre raro y agresivo. Este informe de caso detalla el diagnóstico, los desafíos del tratamiento y hace hincapié en la atención multidisciplinaria para mejorar los resultados en pacientes con LMC.
Área de la Ciencia:
- Hematología Hematología.
- Oncología Oncología.
Sus antecedentes:
- La mastocitosis sistémica (SM, por sus siglas en inglés) implica la proliferación de mastocitos clonales.
- La leucemia de células de mastocitos (LCM) es el subtipo de EM más agresivo con mal pronóstico.
Objetivo del estudio:
- Para reportar un caso de LMC, detallando las características clínicas y el tratamiento.
- Revisar las estrategias terapéuticas actuales y emergentes para la LMC.
- Hacer hincapié en la necesidad de conciencia clínica y atención multidisciplinaria.
Principales métodos:
- Informe de caso de una mujer de 66 años de edad, paciente de MCL.
- Revisión de la literatura actual sobre la EM y la LMC.
- Análisis de los desafíos de diagnóstico y las decisiones de tratamiento.
Principales resultados:
- El caso pone de relieve la complejidad en el diagnóstico y el manejo de la LMC.
- Los tratamientos actuales incluyen el manejo sintomático, los inhibidores de KIT y el trasplante de células madre.
- La revisión de la literatura identifica protocolos de tratamiento estandarizados y limitados.
Conclusiones:
- La LMC requiere un enfoque integral y multidisciplinario para obtener resultados óptimos para los pacientes.
- El diagnóstico precoz y preciso es crucial para una gestión eficaz.
- Las terapias emergentes ofrecen potencial para mejorar la supervivencia en pacientes con LMC.
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