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Updated: Feb 12, 2026

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Solución de calcio hidroxiapatita y polimicronutrientes en el rejuvenecimiento de la mano: un estudio clínico y in

Gladstone Eustáquio de Lima Faria¹, Cibele Hasmann², Renata M M Viana³

¹Instituto Boggio, São Paulo, São Paulo, Brazil.

Journal of cosmetic dermatology

|February 11, 2026

Resumen

El hidroxiapatito de calcio (CaHA) combinado con polimicronutrientes (PMN) mostró una mayor actividad biológica in vitro en comparación con el CaHA en solución salina. Clínicamente, tanto CaHA + PMN como CaHA + solución salina proporcionaron resultados comparables de rejuvenecimiento de la mano.

Área de la Ciencia:

Dermatología y Medicina Estética.
Ciencia de los Biomateriales Ciencia de los Biomateriales.
Biología celular Biología celular.

Sus antecedentes:

La hidroxiapatita de calcio (CaHA) es un relleno biostimulador aprobado por la FDA para el rejuvenecimiento de las manos.
Las soluciones de polimicronutrientes (PMN) se exploran para mejorar el metabolismo celular y la regeneración de la matriz extracelular (ECM) con CaHA.

Objetivo del estudio:

Para comparar los efectos biológicos y clínicos del CaHA diluido en solución de PMN frente a la solución salina para el rejuvenecimiento de las manos.
Para evaluar la proliferación de fibroblastos, la expresión génica ECM y los resultados clínicos de las formulaciones de CaHA.

Principales métodos:

In vitro: se evaluó la proliferación de fibroblastos y la expresión génica ECM (COL1A1, COL3A1, ELN) después de la exposición a CaHA + PMN o CaHA + solución salina.
Clínico: En un ensayo prospectivo, dividido en manos, doble ciego (n=22) se evaluó la Escala de Calificación de la Mano (HGS), la Escala de Mejora Estética Global (GAIS), la hidratación de la piel y el grosor dérmico.

Principales resultados:

In vitro: CaHA + PMN demostró un aumento de la proliferación de fibroblastos y una regulación al alza de la expresión génica COL1A1 y ELN en comparación con CaHA + solución salina.
Clínicamente: Ambas formulaciones mejoraron significativamente la HGS, la hidratación de la piel y el grosor dérmico sin diferencias significativas entre los grupos.
Tanto el GAIS evaluado por el investigador como la satisfacción del paciente mejoraron en ambos grupos.

Conclusiones:

CaHA + PMN y CaHA + solución salina produjeron resultados clínicos comparables para el rejuvenecimiento de la mano.
Los resultados in vitro sugieren que CaHA + PMN ha aumentado la actividad biológica, lo que justifica una mayor investigación.
El potente efecto bioestimulador del CaHA puede enmascarar los beneficios aditivos del PMN en entornos clínicos.

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