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Updated: Feb 12, 2026
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Experimental Model of Ligature-Induced Peri-Implantitis in Mice
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Cambios longitudinales en el microbioma periimplantario después de la colocación del implante: un estudio de
Blanca Vílchez1, Cristina Chamorro2, Elena Figuero1,2
1Postgraduate Clinic of Periodontology, School of Dentistry, University Complutense, Madrid, Spain.
Clinical oral implants research
|February 11, 2026
Resumen
El microbioma periimplantado madura durante 3 años, volviéndose más diverso y estructurado, mientras que el nivel óseo marginal permanece estable. La colonización microbiana temprana puede afectar la salud periimplantaria a largo plazo.
Área de la Ciencia:
- Microbiología oral microbiología oral.
- Implantología dental implantología dental.
- Periodontología periodontología.
Sus antecedentes:
- El microbioma submucoso periimplantado juega un papel crucial en el éxito de los implantes dentales.
- Comprender sus cambios longitudinales durante la cicatrización y la maduración es vital para predecir los resultados clínicos.
Objetivo del estudio:
- Para investigar los cambios longitudinales en el microbioma submucoso peri-implantado durante 3 años.
- Asociar estos cambios microbianos con los resultados clínicos y radiográficos, incluidos los cambios en el nivel óseo marginal (MBL).
Principales métodos:
- Un seguimiento de 3 años de un subconjunto de ensayo clínico controlado aleatorizado.
- Muestras de placa submucosales analizadas a través de la secuenciación del gen 16S rRNA a 1 semana, 4 semanas y 3 años después de la implantación.
- Nivel óseo marginal (MBL) y parámetros clínicos evaluados en múltiples puntos de tiempo.
Principales resultados:
- La riqueza y diversidad del microbioma periimplantado aumentó significativamente en 3 años (p < 0.0001).
- Las primeras biopelículas cambiaron de anaerobios facultativos a taxones anaerobios / proteolíticos, incluidos Prevotella y Porphyromonas gingivalis.
- El nivel óseo marginal (MBL) se mantuvo estable, con remodelación supracrestal fisiológica temprana observada.
Conclusiones:
- El microbioma periimplantario madura en una comunidad más diversa y estructurada durante 3 años.
- El nivel óseo marginal estable (MBL) con remodelación temprana sugiere una integración exitosa.
- Los primeros patrones de colonización microbiana pueden influir en la salud y estabilidad periimplantaria a largo plazo.
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