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Evaluación de la eficacia de la ciproheptadina en la acatisia inducida por neurolepticos agudos: un ensayo controlado
Narges Shams-Alizadeh1, Azad Maroufi1, Khaled Rahmani2
1Department of Psychiatry, Neuropsychological Research Center, Kurdistan University of Medical Sciences.
Journal of clinical psychopharmacology
|February 11, 2026
Resumen
La ciproheptadina trata eficazmente la acatisia inducida por antipsicóticos, reduciendo significativamente los síntomas como la angustia y las medidas objetivas. Este medicamento se muestra prometedor como una alternativa para el manejo de este efecto secundario común.
Área de la Ciencia:
- La psiquiatría es la psiquiatría.
- Farmacología clínica Farmacología clínica.
- La neurociencia es la neurociencia.
Sus antecedentes:
- La acatisia es un efecto secundario frecuente y angustioso de los medicamentos antipsicóticos.
- Tiene un impacto negativo en la adherencia del paciente y en los resultados del tratamiento.
- La evaluación de tratamientos efectivos para la acatisia inducida por neurolepticos es crucial.
Objetivo del estudio:
- Evaluar la eficacia de la ciproheptadina frente al placebo en el tratamiento de la acatisia aguda inducida por neurolepticos.
- Para cuantificar la reducción de los síntomas de la acatisia utilizando la Escala de Clasificación de la Acatisia de Barnes (BARS).
Principales métodos:
- Se realizó un ensayo controlado aleatorizado doble ciego con 50 pacientes psiquiátricos internados diagnosticados con acatisia inducida por neurolepticos.
- Los participantes recibieron ciproheptadina (4 mg cada 12 horas) o un placebo.
- Los síntomas de acatisia se midieron utilizando el BARS al inicio y en los días 4 y 7 posteriores a la intervención.
Principales resultados:
- La ciproheptadina redujo significativamente las puntuaciones de BARS en comparación con el placebo en los días 4 y 7 (P <0,001).
- Se observaron mejoras significativas en los síntomas globales, de angustia, objetivos y subjetivos de acatisia (P<0,05).
- El número necesario para tratar (NNT) fue de aproximadamente 2 pacientes, con una reducción absoluta del riesgo (ARR) de 0,52.
Conclusiones:
- La ciproheptadina demuestra una eficacia significativa en la reducción de los síntomas de acatisia inducidos por antipsicóticos.
- Presenta un tratamiento alternativo potencial para la acatisia, con una eficacia favorable en comparación con otros agentes.
- La somnolencia fue un efecto secundario notable, pero la ciproheptadina no mostró diferencias significativas en el aumento del apetito entre los grupos.
Palabras clave:
La acatisia aguda es una acatisia aguda.Los medicamentos antipsicóticos también son medicamentos antipsicóticos.ciproheptadina y ciproheptadina.Más Videos Relacionados
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