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Explorando la transformación del carcinoma basal adenoide al carcinoma de células escamosas del cuello uterino
Ruyi Ma1,2, Yan Jin3, Zhe Lei2
1Department of Pathology, Wuxi No. 2 People's Hospital, Jiangnan University Medical Center, Affiliated Wuxi Clinical College of Nantong University, Wuxi, PR China.
The Journal of pathology
|February 11, 2026
Resumen
El carcinoma basal adenóide (ABC) puede progresar a carcinoma de células escamosas (SCC) a través de nidos de transición (TN). Comprender este espectro es clave para el tratamiento del cáncer de cuello uterino, con una histerectomía potencialmente adecuada para ABC con TNs.
Área de la Ciencia:
- Patología ginecológica patología ginecológica.
- Biología del cáncer Biología del cáncer.
- El diagnóstico molecular es el diagnóstico molecular.
Sus antecedentes:
- El carcinoma basal adenóide (ABC) es un tumor cervical raro con un pronóstico generalmente bueno.
- El ABC mixto con el carcinoma de células escamosas invasivo (CCS) presagia un mal resultado.
- Los nidos de transición (TNs) pueden representar una etapa intermedia entre ABC y SCC.
Objetivo del estudio:
- Para dilucidar la relación histomorfológica y molecular entre ABC, TNs y SCC.
- Para identificar los marcadores moleculares que distinguen estos subtipos de tumores cervicales.
- Informar las estrategias terapéuticas para ABC y SCC mixtos.
Principales métodos:
- Análisis retrospectivo de 20 casos de ABC con CCS, TN o lesiones intraepiteliales escamosas de alto grado (HSIL) concurrentes.
- Evaluación histomorfológica de las interfaces tumor-tumor.
- El perfil espacial digital (DSP) y la inmunohistoquímica en cuatro casos.
Principales resultados:
- Los TN se ubicaron entre ABC y SCC, mostrando atipia central y expresión de células basaloides de BCL-2.
- DSP identificó CK13 y SCCA2 como genes de expresión diferencial que distinguen a los TN de otros subtipos.
- La inmunohistoquímica validó CK13 y SCCA2 como marcadores específicos para los TN.
Conclusiones:
- Este estudio demuestra un espectro de enfermedad de ABC que progresa a SCC a través de TNs, ofreciendo información sobre la patogénesis de SCC.
- Los TN representan una fase de transición distinta entre ABC y SCC.
- Se puede considerar la histerectomía total para el ABC con TNs, a la espera de estudios más grandes.
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