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Eficacia del apremilast en pacientes con Pustulosis Palmoplantar: un estudio de 28 semanas en el mundo real

Yohei Takahashi¹, Teppei Hagino¹, Hidehisa Saeki²

¹Department of Dermatology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.

The Journal of dermatology

|February 11, 2026

Resumen

Apremilast efectivamente redujo los síntomas y mejoró la calidad de vida de pacientes con pustulosis palmoplantar (PPP) de moderada a grave en entornos del mundo real. El inhibidor oral de la PDE4 demostró mejoras significativas durante 28 semanas con una buena tolerabilidad.

Área de la Ciencia:

Dermatología Dermatología dermatología.
Farmacología Farmacología.
La investigación clínica es la investigación clínica.

Sus antecedentes:

La pustulosis palmoplantar (PPP) es una afección inflamatoria crónica de la piel que afecta las palmas y las plantas.
Los tratamientos existentes para la PPP de moderada a grave a menudo tienen limitaciones, lo que requiere la exploración de opciones sistémicas.
Apremilast, un inhibidor oral de la fosfodiesterasa 4 (PDE4), es prometedor, pero requiere datos de efectividad en el mundo real.

Objetivo del estudio:

Evaluar la efectividad y tolerabilidad del apremilast en el mundo real de 28 semanas en pacientes adultos con PPP de moderado a severo.
Evaluar el impacto del apremilast en la gravedad de la enfermedad y la calidad de vida en un entorno de práctica clínica de rutina.

Principales métodos:

Un estudio retrospectivo de un solo centro incluyó a 15 pacientes adultos con PPP de moderado a severo.
Los pacientes recibieron apremilast 30 mg dos veces al día durante 28 semanas.
El Índice de Área y Gravedad de Pustulosis Palmoplantar (PPPASI) y el Índice de Calidad de Vida en Dermatología (DLQI) se evaluaron al inicio y en las semanas 4, 16 y 28.

Principales resultados:

Se observaron reducciones significativas y continuas en las puntuaciones medias de PPPASI y DLQI hasta la semana 28.
En la semana 28, las reducciones porcentuales medias desde el inicio fueron del 76,9% para PPPASI y del 63,4% para DLQI.
Las tasas de respuesta alcanzadas en la semana 28 incluyeron PPPASI 50 (90,0%), PPPASI 75 (60,0%), PPPASI 90 (30,0%) y DLQI 0/1 (42,9%).

Conclusiones:

Apremilast es una opción de tratamiento eficaz y tolerable para pacientes con PPP de moderada a grave que requieren terapia sistémica en la práctica del mundo real.
El estudio indica beneficios clínicos sostenidos durante 28 semanas, con eventos adversos manejables, principalmente diarrea.
Se necesitan más estudios a gran escala para confirmar la eficacia y la sostenibilidad a largo plazo del apremilasto en el manejo de la PPP.

Palabras clave:

IL-8 es una IL-8.El PPPASI es el PPPASI.Apremilast es el último.La pustulosis palmoplantar también es conocida como pustulosis palmoplantar.mundo real en el mundo real.

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