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Asociación del oxígeno no puenteante con la citocompatibilidad en el cerio y el cobalto en el vidrio biológico 58S

Murli Manohar¹, Kantesh Balani¹

¹Department of Materials Science and Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, Uttar Pradesh, India.

ACS biomaterials science & engineering

|February 11, 2026

Resumen

El dopaje de cobalto y cerio mejora el vidrio bioactivo para la reparación ósea al mejorar la resistencia mecánica y promover el crecimiento celular mientras inhibe las bacterias. Este vidrio bioactivo muestra un potencial significativo para aplicaciones de reemplazo óseo.

Área de la Ciencia:

Ciencia de los Biomateriales Ciencia de los Biomateriales.
Ciencia de los materiales Ciencia de los materiales.
Ingeniería Biomédica Ingeniería Biomédica.

Sus antecedentes:

El vidrio bioactivo (BG) es excelente para la regeneración ósea, pero carece de propiedades antibacterianas.
El cobalto (Co) y el cerio (Ce) fueron investigados como dopantes para impartir efectos antibacterianos y mejorar las propiedades mecánicas.

Objetivo del estudio:

Desarrollar un nuevo vidrio bioactivo dopado con cobalto y cerio (2.5Ce5CoBG).
Para evaluar su potencial osteogénico, actividad antibacteriana y propiedades mecánicas para aplicaciones de reemplazo óseo.

Principales métodos:

Se utilizó la sinterización con plasma de chispa (SPS) para crear pellets densos de 2.5Ce5CoBG.
La bioactividad in vitro se evaluó a través de la formación de una capa de apatita.
Se evaluó la eficacia antibacteriana contra *Escherichia coli* y *Staphylococcus aureus*.
Se analizó la respuesta de las células similares a los osteoblastos (MG-63, NIH 3T3), incluida la adhesión, la proliferación y la deposición de la matriz.

Principales resultados:

2.5Ce5CoBG exhibió una nano-dureza significativamente mejorada (~5.61 GPa) y un módulo de Young (~75 GPa) en comparación con el BG sin dopaje.
Los estudios in vitro mostraron una rápida formación de la capa de apatita, lo que indica su bioactividad.
2.5Ce5CoBG redujo notablemente la viabilidad bacteriana y la adhesión tanto para *S. aureus* como para *E. coli*.
Las nanopartículas y pellets de BG dopados demostraron una mayor viabilidad celular, adhesión y proliferación de las células MG-63 y NIH 3T3.

Conclusiones:

El dopaje de cobalto y cerio mejoró con éxito las propiedades mecánicas y la bioactividad del vidrio bioactivo 58S.
El 2.5Ce5CoBG desarrollado exhibe una potente actividad antibacteriana y promueve una respuesta celular similar a la de los osteoblastos.
Este vidrio bioactivo dopado muestra una promesa significativa para terapias avanzadas de reemplazo óseo.

Palabras clave:

58S vidrio bioactivo de vidrio 58S antibacteriano y antibacteriano.la citocompatibilidad y la citocompatibilidad.El dopaje es el dopaje.Sinterizado con plasma de chispa sinterizado con plasma de chispa

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