Video Experimental Relacionado
Updated: Feb 12, 2026
06:23
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
Published on: February 15, 2019
14.9K
Aumento de la diversidad de la microbiota intestinal en pacientes con retinitis pigmentosa e implicaciones para los
Tomoko Hasegawa1,2, Sachiko Iwai1, Hanako Ohashi Ikeda1,3
1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Investigative ophthalmology & visual science
|February 11, 2026
Resumen
Los pacientes con retinitis pigmentosa (RP) muestran bacterias intestinales alteradas. El tratamiento con antibióticos en ratones RP mejoró la salud de la retina al reducir la inflamación, lo que sugiere la modulación de la microbiota intestinal como una terapia potencial para RP.
Área de la Ciencia:
- Oftalmología Oftalmología.
- Microbiología Microbiología.
- Inmunología Inmunología.
Sus antecedentes:
- La inflamación es una característica común en la retinitis pigmentosa (RP), que afecta los resultados visuales.
- La microbiota intestinal influye significativamente en los procesos inflamatorios en el cuerpo.
Objetivo del estudio:
- Para investigar la asociación entre la composición de la microbiota intestinal y la retinitis pigmentosa.
- Explorar el potencial terapéutico de la modulación de la microbiota intestinal en RP.
Principales métodos:
- Secuenciación del gen 16S rRNA de muestras de heces de 103 pacientes con RP y 64 controles sanos.
- Comparación de la diversidad y abundancia de la microbiota intestinal entre grupos, incluidos pacientes con RP con y sin edema macular cistoide (EMC).
- Evaluación de la estructura y función de la retina en ratones modelo RP tratados con antibióticos.
Principales resultados:
- Los pacientes con RP exhibieron una diversidad de microbiota intestinal significativamente mayor que los individuos sanos.
- Los pacientes de RP con EMC mostraron una mayor diversidad y una mayor abundancia de bacterias específicas (Romboutsia, Ruminococcus).
- El tratamiento con antibióticos en ratones RP preservó la función retiniana, redujo la pérdida de fotorreceptores, suprimió la apoptosis y reguló a la baja los componentes de la vía inflamatoria del NLRP3.
Conclusiones:
- Se observan perfiles distintos de microbiota intestinal en pacientes con RP en comparación con individuos sanos.
- La administración de antibióticos atenuó la progresión de la enfermedad en un modelo de ratón RP.
- Dirigirse a la microbiota intestinal representa una vía terapéutica prometedora para la retinitis pigmentaria.
Videos de Conceptos Relacionados
01:18Increasing Function
401
An increasing function exhibits a rise in output values as input values increase. This behavior is depicted graphically as a curve or line that slopes upward from left to right. Such a function satisfies the condition that if x1 < x2, then f(x1) < f(x2), indicating that the function values grow with increasing inputs. This concept is fundamental in understanding growth trends across various domains, such as population dynamics, financial investments, or resource consumption.The...
401
01:13Cell Diversity
5.2K
The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular...
Multicellular...
5.2K
01:24Diversity of Archaea II
548
Archaea, one of the three domains of life, exhibit remarkable diversity and adaptability, thriving in both extreme and moderate environments. Historically, most identified archaea have been classified into two major phyla: Euryarchaeota and Crenarchaeota. However, recent molecular studies have expanded this classification to include three additional phyla: Thaumarchaeota, Nanoarchaeota, and Korarchaeota, each exhibiting unique characteristics and ecological roles.Thaumarchaeota: Mesophiles...
548
01:15Diversity of Protists I
1.2K
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
1.2K
01:27Diversity of Protists II
1.2K
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
1.2K
01:30Diversity of Archaea I
680
Archaea, a domain of single-celled microorganisms, are classified into five major phyla based on genetic and biochemical characteristics: Euryarchaeota, Crenarchaeota, Thaumarchaeota, Korarchaeota, and Nanoarchaeota. Among these, the phylum Euryarchaeota is notable for its remarkable diversity in morphology, metabolism, and ecological adaptations.Morphological and Metabolic DiversityMembers of Euryarchaeota exhibit a variety of cellular shapes, including rods and cocci. Their metabolic pathways...
680