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Monitoreo de la temperatura ratiométrica libre de autofluorescencia con nanotermómetros luminiscentes persistentes de
Lingling Qiu1, Jiahui Tan1, Jiayi Chen1
1The Key Lab of Health Chemistry & Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering & Materials Science, Soochow University, Suzhou, 215123, China.
Analytical and bioanalytical chemistry
|February 11, 2026
Resumen
Los investigadores desarrollaron nuevos termómetros luminiscentes utilizando nanopartículas de Zn2GeO4:Bi,Tb para un monitoreo preciso de la temperatura fisiológica. Esta tecnología de autocalibración supera las interferencias, permitiendo mediciones precisas para estudios biológicos y patológicos.
Área de la Ciencia:
- Ciencia de los materiales Ciencia de los materiales.
- Nanotecnología La nanotecnología es la nanotecnología.
- Ingeniería Biomédica Ingeniería Biomédica.
Sus antecedentes:
- Los termómetros luminiscentes son vitales para el monitoreo de la temperatura fisiológica, crucial para la comprensión de los procesos biológicos y patológicos.
- Los métodos existentes sufren problemas de precisión y sensibilidad debido a las fluctuaciones instrumentales y la autofluorescencia tisular.
Objetivo del estudio:
- Desarrollar nuevas nanopartículas luminiscentes para un monitoreo de temperatura altamente preciso y sensible.
- Para crear un sistema de autocalibración que elimine las interferencias instrumentales y espectrales.
- Diseñar una plataforma theranostic para la terapia simultánea y la retroalimentación de la temperatura.
Principales métodos:
- Las nanopartículas sintetizadas Zn2GeO4:Bi,Tb (ZGO:Bi,Tb) exhiben una luminiscencia racionométrica persistente dependiente de la temperatura.
- Utilizó un enfoque de abajo hacia arriba para la fabricación de nanopartículas.
- Nanopartículas ZGO:Bi,Tb integradas con el verde de la indocianina (ICG) para crear una plataforma theranostic.
Principales resultados:
- Las nanopartículas ZGO:Bi,Tb demostraron una luminiscencia persistente ratiométrica dependiente de la temperatura entre 298 y 358 K.
- La medición ratiométrica (I545 / I585) permitió la autocalibración, reduciendo la desviación de temperatura al 0,88%.
- La plataforma ZGO:Bi,Tb-ICG logró un monitoreo preciso de la temperatura durante la terapia fototérmica (PTT) con una correlación de 0,991 con la termografía infrarroja.
Conclusiones:
- Las nanopartículas ZGO:Bi,Tb desarrolladas proporcionan un método altamente preciso y sensible para el monitoreo de la temperatura, superando las limitaciones comunes.
- La plataforma theranostic integrada permite PTT simultáneo y una retroalimentación de temperatura precisa, mostrando el potencial para aplicaciones biomédicas.
- Este estudio presenta un nuevo paradigma para el monitoreo de la temperatura en la investigación biológica y el análisis del estado patológico.
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