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Ptprf es el receptor conservado de los efectos glucogénicos de la asprosina en los vertebrados
Zhiquan Liu1, Pengyu Wang1, Yixuan Hu1
1College of Life Sciences, Northwest Normal University, Lanzhou 730070, China.
Cell reports
|February 11, 2026
Resumen
Los investigadores identificaron el receptor de proteína tirosina fosfatasa F (Ptprf) como el receptor de la asprosina, una hormona que regula la glucosa. Este descubrimiento en peces cebra y mamíferos ofrece nuevos objetivos terapéuticos para la diabetes y la obesidad.
Área de la Ciencia:
- Endocrinología Endocrinología.
- Investigación Metabólica de Investigación.
- Biología Molecular Biología Molecular
Sus antecedentes:
- La asprosina es una hormona inducida por el ayuno crítica para la homeostasis de la glucosa.
- El receptor específico para la asprosina ha permanecido sin identificar, lo que dificulta la comprensión de sus funciones metabólicas.
Objetivo del estudio:
- Para identificar el receptor de la asprosina y aclarar su papel en el metabolismo de la glucosa.
- Para investigar la conservación evolutiva de la interacción entre la asprosina y el receptor.
Principales métodos:
- Se utilizaron modelos de pez cebra para demostrar la conservación evolutiva e identificar el receptor de la asprosina.
- Se realizaron ensayos de unión para confirmar Ptprf como el receptor de interacción en el hígado del pez cebra.
- Realizó estudios de ablación genética y sobreexpresión en peces cebra y utilizó ratones knockout Ptprf para su validación.
Principales resultados:
- Identificó el receptor de proteína tirosina fosfatasa F (Ptprf) como el receptor de la asprosina.
- Se demostró que Ptprf se conserva evolutivamente y se une a la asprosina con alta afinidad en peces cebra y mamíferos.
- La alteración genética de Ptprf en peces cebra y ratones abrogó los efectos de aumento de la glucosa de la asprosina.
Conclusiones:
- Ptprf es un receptor evolucionariamente conservado para la asprosina en los vertebrados.
- Este hallazgo proporciona información mecánica crucial sobre el papel de la asprosina en la homeostasis de la glucosa.
- La vía asprosina-Ptprf representa un objetivo terapéutico potencial para trastornos metabólicos como la diabetes y la obesidad.
Palabras clave:
CP: el metabolismo.CP: neurociencia y neurociencia.como la asprosina y la asprosina.La glucosa glucosa es la glucosa.El hombre humano humano humano humano humano.El receptor de insulina es el receptor de la insulina.El ratón el ratón el ratón el ratón.Ptprff es el nombre de la empresa.El pez cebra es un pez cebra.
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