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Mapeo de los cuatro ejes de la adiposidad-citocina inflamatoria-tromboembolismo venoso Paisaje de riesgo de

Rongrong Li¹, Hongping Luo¹, Ye Tian¹

¹Nursing Department, Tongii Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

|February 11, 2026

Resumen

La obesidad general y la grasa corporal baja aumentan el riesgo de tromboembolismo venoso (TEV), con la inflamación mediando parcialmente estos efectos. La grasa de la parte inferior del cuerpo.

Área de la Ciencia:

Genética La genética.
Epidemiología La epidemiología.
Enfermedades cardiovasculares Enfermedades cardiovasculares Enfermedades cardiovasculares Enfermedades cardiovasculares Enfermedades cardiovasculares Enfermedades cardiovasculares Enfermedades cardiovasculares Enfermedades cardiovasculares

Sus antecedentes:

Las métricas estándar de obesidad como el IMC no diferencian la distribución de la grasa, lo que limita la inferencia causal para el tromboembolismo venoso (TEV).
La obesidad es una condición heterogénea con diferentes patrones de distribución de grasa que influyen en los resultados de salud.
Comprender los depósitos específicos de adiposidad que contribuyen al riesgo de TEV es crucial para la prevención específica.

Objetivo del estudio:

Investigar la relación causal entre los diferentes ejes de la obesidad y el riesgo de TEV utilizando la aleatorización mendeliana (AR).
Explorar el papel mediador de las citoquinas inflamatorias en la asociación entre la obesidad y la TEV.
Para diferenciar el riesgo de TEV conferido por la obesidad general frente a la distribución de grasa corporal inferior.

Principales métodos:

Se utilizaron instrumentos significativos de todo el genoma para cuatro ejes de adiposidad definidos por resonancia magnética: obesidad general, grasa corporal inferior, grasa muscular dominante y grasa periférica.
Evaluó la TEV y sus subtipos (trombosis venosa profunda [TVP] y embolia pulmonar [EP]) utilizando datos de FinnGen-R12.
Empleó ponderación de varianza inversa, estimadores de MR complementarios y MR de mediación en dos pasos para analizar la causalidad y las vías de mediación.

Principales resultados:

El eje de obesidad general aumentó significativamente los riesgos de TEV, TVP y EP (todos P<0.05).
El eje de grasa corporal inferior también elevó los riesgos de TEV y TVP (P_FDR <0.05).
Los mediadores inflamatorios como CTACK / CCL27, Beta-NGF y MCP-3 explicaron parcialmente la asociación entre la obesidad general y la TEV / EP.

Conclusiones:

La inflamación interviene parcialmente en el vínculo entre la obesidad general y la TEV, incluidos sus subtipos.
La acumulación de grasa en la parte inferior del cuerpo contribuye principalmente al riesgo de TEV / DVT a través de vías hemodinámicas venosas locales.
Este estudio pone de relieve la importancia de considerar la distribución de la grasa en la evaluación del riesgo de TEV y las estrategias de prevención.

Palabras clave:

ejes de adiposidad.La trombosis venosa profunda es una trombosis venosa profunda.La aleatorización mendeliana es una aleatorización mendeliana.Obesidad obesidad.embolia pulmonar por embolia pulmonar, es decir, por embolia pulmonar.Tromboembolismo venoso y tromboembolismo venoso.

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