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Verificación de los intervalos de referencia para las pruebas bioquímicas de rutina utilizando el reflimR en adultos
Levent Deniz1, Ozlem Demirelce2
1Department of Medical Biochemistry, University of Health Sciences Türkiye, Istanbul Training and Research Hospital, Istanbul, Türkiye.
PloS one
|February 11, 2026
Resumen
Este estudio verificó los intervalos de referencia (IR) para adultos turcos utilizando el método reflimR, encontrando discrepancias con los IR del fabricante debido a las diferencias en la población. El algoritmo de reflimR ofrece una forma accesible de calcular y verificar los RI.
Área de la Ciencia:
- La bioquímica clínica es la bioquímica clínica.
- Medicina de laboratorio y medicina de laboratorio.
- Salud de la población Salud de la población
Sus antecedentes:
- El establecimiento de intervalos de referencia precisos (IR) es crucial para interpretar los resultados de las pruebas clínicas de laboratorio.
- Los RIs proporcionados por el fabricante pueden no reflejar con precisión las diversas poblaciones, lo que requiere una verificación local.
- El método reflimR presenta un nuevo enfoque para la estimación y verificación de RI indirecta.
Objetivo del estudio:
- Para verificar los intervalos de referencia (IR) para 19 pruebas de bioquímica de rutina en la población turca adulta.
- Para comparar las RIs derivadas utilizando el método reflimR con las RIs proporcionadas por el fabricante.
- Para evaluar el rendimiento del algoritmo de reflimR en comparación con otros métodos de estimación de RI indirectos.
Principales métodos:
- Utilizó el algoritmo reflimR para evaluar RIs para 19 parámetros bioquímicos analizados en analizadores Beckman Coulter.
- Se emplearon cinco enfoques indirectos (reflimR, refineR, KOSMIC, Hoffmann, Bhattacharya) para la estimación del RI en hombres y mujeres.
- Aplicado un algoritmo de semáforo basado en la incertidumbre admisible para la verificación del límite de RI.
Principales resultados:
- 40 de los 76 límites de RI calculados por reflimR fueron aceptados, 21 requerían verificación y 15 fueron rechazados con respecto a los valores del fabricante.
- El método reflimR mostró resultados generalmente concordantes con otros métodos indirectos, excepto para ALT, GGT y bilirrubina total.
- Las fallas en la verificación destacan las posibles variaciones étnicas, de sexo, edad y geográficas entre las poblaciones.
Conclusiones:
- El algoritmo de reflimR proporciona una herramienta rápida y accesible para el cálculo y la verificación de RIs.
- Las discrepancias en los IR subrayan la importancia de la verificación específica de la población.
- Factores como la etnia y la demografía influyen significativamente en el establecimiento de RI.
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