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La polifarmacia y las posibles interacciones entre fármacos en pacientes de edad avanzada: un estudio de referencia
Rami Mosleh1, Yazun Jarrar2, Shurouq Ghalib Qadous3
1Department of Clinical and Community Pharmacy, Faculty of Pharmacy, An-Najah National University (www.najah.edu), Nablus, Palestine.
Science progress
|February 11, 2026
Resumen
Las posibles interacciones drogas-drogas (PDI) son comunes en los adultos mayores palestinos, especialmente con más medicamentos. Factores como el estado civil, la región y las enfermedades crónicas influyen en estos riesgos.
Área de la Ciencia:
- Farmacia Clínica Farmacia clínica es la especialidad de la farmacia clínica.
- Salud Pública La salud pública.
- Medicina Geriátrica La medicina geriátrica es una especialidad de la medicina geriátrica.
Sus antecedentes:
- La polifarmacia plantea riesgos significativos en la atención médica, especialmente para los ancianos y las personas con enfermedades crónicas.
- Las posibles interacciones entre fármacos (pDDI) son una preocupación importante en el manejo de múltiples medicamentos.
- La evaluación de las pDDI en Palestina es crucial para comprender los desafíos de la atención médica.
Objetivo del estudio:
- Determinar la prevalencia y los factores asociados con PDDI en adultos mayores en Jerusalén, la Franja de Gaza y Cisjordania.
- Establecer una evaluación de referencia de las pDDI antes de la crisis palestina de octubre de 2023.
- Para identificar los determinantes demográficos y clínicos de las pDDI.
Principales métodos:
- Un estudio transversal de 403 participantes realizado entre mayo y agosto de 2023.
- Un simple muestreo aleatorio de los registros médicos de los pacientes.
- Los datos recopilados a través de cuestionarios en línea administrados en farmacias y hospitales, analizados utilizando SPSS v21.
Principales resultados:
- Se observó una alta prevalencia de PDDI de moderada a grave en la población palestina.
- El aumento en el número de medicamentos, el estado matrimonial y la residencia en el norte de Cisjordania se relacionaron con mayores PDDI.
- Los diagnósticos de dislipidemia y diabetes mellitus se asociaron con un mayor riesgo de IDPD moderadas.
Conclusiones:
- Los factores clínicos y demográficos influyen significativamente en el riesgo de PDDI en pacientes palestinos.
- Los proveedores de atención médica deben considerar estos factores para mitigar los riesgos de la polifarmacia.
- Este estudio proporciona datos básicos esenciales sobre las pDDI en Palestina antes de una crisis importante.
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