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Cáncer cervical localmente avanzado: ¿cuál es el tratamiento sistémico preferido?
Matthew L Flint1, Maureen E Byrne1, Claire F Friedman2,3,4
11Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Journal of the National Comprehensive Cancer Network : JNCCN
|February 11, 2026
Resumen
El tratamiento de cáncer cervical localmente avanzado (LACC) con quimioradioterapia (CRT) tiene una tasa de supervivencia a 5 años del 74%. Una nueva investigación explora la adición de quimioterapia o inmunoterapia a la TCR para mejorar los resultados para los pacientes con CACL.
Área de la Ciencia:
- Oncología Ginecológica Oncología Ginecológica.
- Radioncología Oncología de Radiación.
- Oncología médica Oncología médica.
Sus antecedentes:
- El cáncer de cuello uterino es un problema de salud mundial significativo, especialmente para las mujeres.
- El tratamiento estándar actual para el cáncer cervical localmente avanzado (LACC) implica quimioradioterapia (CRT) seguida de braquiterapia.
- A pesar de la CRT, la tasa de supervivencia a 5 años para los pacientes con LACC es de aproximadamente 74%, lo que indica la necesidad de mejorar las estrategias terapéuticas.
Objetivo del estudio:
- Revisar el contexto histórico de la TCR basada en cisplatino para el CACL.
- Examinar los datos emergentes sobre los nuevos enfoques de tratamiento para el LACC.
- Evaluar los beneficios potenciales de la quimioterapia de consolidación, la quimioterapia de inducción y la inmunoterapia en el manejo del LACC.
Principales métodos:
- Revisión de ensayos controlados aleatorios prospectivos y resultados publicados recientemente.
- Análisis de los datos sobre los regímenes de quimioterapia sistémica y inmunoterapia.
- Revisión histórica de la quimioradioterapia concurrente (CRT) en el tratamiento del LACC.
Principales resultados:
- La CRT simultánea basada en cisplatino es el estándar establecido para LACC.
- Pruebas recientes sugieren beneficios potenciales de supervivencia con regímenes alternativos.
- La quimioterapia de consolidación, la quimioterapia de inducción y la inmunoterapia están bajo investigación.
Conclusiones:
- Si bien la TCR es una piedra angular del tratamiento del LACC, su eficacia tiene limitaciones.
- La evidencia emergente apoya la investigación de terapias sistémicas adicionales para mejorar las tasas de supervivencia.
- La investigación adicional sobre la quimioterapia de consolidación, la quimioterapia de inducción y la inmunoterapia es prometedora para avanzar en el cuidado de LACC.
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