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La supresión de la función ovárica en el cáncer de mama HR-positivo, HER2-positivo: un análisis exploratorio del

Soong June Bae^1,2, Sohyun Moon³, Yoonwon Kook^1,2

¹1Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Journal of the National Comprehensive Cancer Network : JNCCN

|February 11, 2026

Resumen

La adición de supresión de la función ovárica (OFS) a la terapia endocrina mejora significativamente la supervivencia libre de enfermedad y la supervivencia general para las mujeres premenopáusicas con cáncer de mama HR-positivo, HER2-positivo. Los inhibidores de la aromatasa mostraron mejores resultados que el tamoxifeno cuando se combinaron con OFS.

Área de la Ciencia:

Oncología Oncología.
Endocrinología Endocrinología.
Los ensayos clínicos son ensayos clínicos.

Sus antecedentes:

Existen datos limitados sobre la efectividad de la supresión de la función ovárica (OFS) en pacientes premenopáusicas con cáncer de mama receptor de hormonas (HR) positivo, HER2-positivo.
Investigar el impacto pronóstico de OFS en esta población específica de pacientes es crucial.

Objetivo del estudio:

Evaluar el impacto de la adición de OFS a la terapia endocrina adyuvante en la supervivencia libre de enfermedad (DFS) y la supervivencia global (OS) en mujeres premenopáusicas con cáncer de mama HR-positivo, HER2-positivo en etapa temprana.
Para comparar la eficacia del tamoxifeno (TAM) frente a los inhibidores de la aromatasa (IA) cuando se utiliza con OFS.

Principales métodos:

Análisis de los datos a nivel de paciente del ensayo HERceptin Adjuvant (HERA) (BIG1-01).
Comparación de los resultados de supervivencia entre los pacientes que recibieron solo TAM frente a los que recibieron terapia endocrina con OFS.
Exploración de las diferencias de pronóstico entre TAM e AI en el grupo OFS.

Principales resultados:

La adición de OFS mejoró significativamente la DFS (HR, 0.68; P=.002) y la OS (HR, 0.62; P=.003) en comparación con TAM solo.
Las tasas de DFS a 10 años fueron del 70,9% con OFS frente al 59,6% con TAM solamente; las tasas de OS a 10 años fueron del 84,7% con OFS frente al 74,0% con TAM solamente.
Dentro del grupo OFS, los inhibidores de la aromatasa (IA) se asociaron con mejores resultados de supervivencia que el tamoxifeno (TAM).

Conclusiones:

La supresión de la función ovárica (OFS) como parte de la terapia endocrina adyuvante puede mejorar los resultados de supervivencia para las mujeres premenopáusicas con cáncer de mama HR-positivo, HER2-positivo.
Estos hallazgos son particularmente relevantes para los pacientes de alto riesgo que reciben quimioterapia y terapia dirigida a HER2.

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