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Análisis dinámico de inserción mecánica de microagujas de gelatina metacriloil bajo condiciones de inserción

Moloud Amini Baghbadorani¹, Masoumeh Zargar², Abdellah Shafieian²

¹Center for Advanced Materials and Manufacturing (CAMM), School of Engineering, Edith Cowan University, Joondalup, WA, 6027, Australia.

Journal of the mechanical behavior of biomedical materials

|February 11, 2026

Resumen

Las microagujas de gelatina metacriloilo (GelMA) (MNs) son prometedoras para la administración de fármacos. Los diseños cónicos cónicos optimizados con soporte de base y velocidades de inserción específicas mejoran la fiabilidad mecánica y la seguridad para uso clínico.

Área de la Ciencia:

Ingeniería de Biomateriales Ingeniería de Biomateriales
Sistemas de suministro de drogas Sistemas de suministro de drogas.
Diseño del Dispositivo Médico Diseño del Dispositivo Médico

Sus antecedentes:

Las microagujas de gelatina metacriloilo (GelMA) ofrecen potencial para aplicaciones mínimamente invasivas.
El rendimiento de las MNs de GelMA en condiciones realistas y parámetros variables no se entiende bien.

Objetivo del estudio:

Para caracterizar el rendimiento mecánico de diferentes geometrías GelMA MN bajo condiciones de inserción realistas.
Para identificar los parámetros de diseño óptimos y la dinámica de inserción para mejorar la fiabilidad y la seguridad de GelMA MN.

Principales métodos:

Se realizaron análisis de elementos finitos (dinámicos y estáticos) en MNs de GelMA cónicos, piramidales y cónicos cónicos.
Evaluación de la fuerza de inserción, el esfuerzo y los factores de seguridad a diferentes velocidades de inserción (2-6 m/s).
Efectos investigados del tiempo de enlace cruzado, la concentración del polímero y el soporte de la base.

Principales resultados:

La geometría cónica cónica exhibió una confiabilidad mecánica superior, equilibrando la fuerza de inserción con la resistencia a la flexión y la curvatura.
El soporte de la base redujo las tensiones máximas y alisó los perfiles de inserción hasta en un 20%.
Se identificó una velocidad de inserción óptima de 3-4 m/s para minimizar el estrés tisular.

Conclusiones:

Un enfoque de diseño integral que integre la geometría, las propiedades del material y la dinámica de inserción es crucial para el desarrollo de GelMA MN.
Los MNs optimizados de GelMA demuestran un potencial de seguridad y eficacia mejorados para la traducción clínica.
Los hallazgos guían el desarrollo de matrices avanzadas de microagujas para la administración de fármacos y la extracción de fluidos.

Palabras clave:

El análisis de elementos finitos.Las microagujas GelMA son microagujas GelMA.Dinámica de inserción de alta velocidad de las dinámicas de inserción de alta velocidad.El rendimiento mecánico.Geometría de las microagujas.

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