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Exposiciones tempranas a ftalatos y plastificantes de reemplazo y cambios en la conectividad funcional cerebral y la
Stephanie M Engel1, Tengfei Li2, Emily J Werder3
1Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Environment international
|February 11, 2026
Resumen
La exposición temprana a los ftalatos y los plastificantes de reemplazo (PRP) afecta el desarrollo del cerebro. Los niños mostraron una disminución de la conectividad funcional, mientras que las niñas mostraron un aumento de la conectividad y el adelgazamiento cortical con la exposición a PRP.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Salud Ambiental Salud del medio ambiente.
- Biología del desarrollo Biología del desarrollo.
Sus antecedentes:
- Los ftalatos y los plastificantes de reemplazo (PRP) son exposiciones ambientales comunes.
- La exposición prenatal y de la primera infancia a los PRP está relacionada con problemas de desarrollo cognitivo y conductual.
- Los impactos potenciales en la estructura y función cerebral durante los períodos críticos de desarrollo no se comprenden completamente.
Objetivo del estudio:
- Investigar la asociación entre la exposición temprana a PRPs y el desarrollo cerebral en niños.
- Examinar los impactos en la conectividad funcional de las redes de estado de reposo y la morfología estructural de las regiones corticales.
- Para identificar las diferencias específicas del sexo en estas asociaciones.
Principales métodos:
- Estudio longitudinal de niños de edades comprendidas entre 2 semanas y 5 años (Baby Connectome Project).
- Adquisición de resonancia magnética funcional estructural y en estado de reposo no sedada durante el sueño natural.
- Análisis de muestras de orina para 17 metabolitos de PRP utilizando ecuaciones de estimación ponderadas por el núcleo y modelos lineales generalizados.
Principales resultados:
- Múltiples metabolitos de PRP se asociaron con una conectividad funcional alterada en el control ejecutivo y las redes de atención dorsal.
- La exposición a PRP se relacionó con una disminución de la conectividad funcional en los niños y un aumento de la conectividad en las niñas.
- Las concentraciones de metabolitos de MiBP en las niñas se asociaron con el adelgazamiento cortical en las regiones del lóbulo temporal.
Conclusiones:
- La exposición temprana a PRP afecta de manera medible la trayectoria de maduración del cerebro.
- Existen diferencias significativas entre los sexos en el impacto de la exposición al PRP en el desarrollo cerebral.
- Estos hallazgos resaltan la importancia de las exposiciones ambientales durante el desarrollo temprano.
Palabras clave:
Salud ambiental de los niños y niñas.Las sustancias químicas que alteran el sistema endocrino.Neurodesarrollo del desarrollo neurológico.Los ftalatos también son ftalatos.Más Videos Relacionados
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