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Asociación entre la conectividad funcional del precúneo izquierdo y el desarrollo neurológico temprano en bebés
Ye Feng1, Xu Li2, Shaohua Bi1
1Department of Neonatology, Anhui Provincial Children's Hospital, Hefei 230051, China.
Brain & development
|February 11, 2026
Resumen
Los bebés prematuros muestran una conectividad cerebral alterada en el precúneo izquierdo, lo que afecta el desarrollo neuroconductual. Estos deterioros funcionales pueden estar vinculados a déficits a largo plazo, informando estrategias de evaluación temprana.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Neurociencia del desarrollo neurológico.
- Neurología Pediátrica.
Sus antecedentes:
- El nacimiento prematuro está relacionado con alteraciones de la red cerebral, lo que podría causar déficits motores y neurocognitivos.
- Los mecanismos neuronales detrás de estos déficits en los bebés prematuros no se comprenden completamente.
Objetivo del estudio:
- Para investigar los cambios en la actividad cerebral funcional de los bebés prematuros.
- Para correlacionar estos cambios con el desarrollo neuroconductual temprano.
Principales métodos:
- Usó imágenes de resonancia magnética funcional en estado de reposo (rs-fMRI) en 15 bebés prematuros y 15 a término.
- Análisis de la amplitud aplicada de las fluctuaciones de baja frecuencia (ALFF), homogeneidad regional (ReHo) y conectividad funcional basada en semillas (FC).
- Las puntuaciones correlacionadas de la Evaluación Neurológica del Comportamiento Neonatal (NBNA) con FC en bebés prematuros.
Principales resultados:
- Los bebés prematuros tenían ALFF y ReHo más altos en el precúneo izquierdo en comparación con los bebés a término.
- Se observó una reducción de la FC entre el precuneo izquierdo y el operculo de Rolandic izquierdo, el putamen derecho y el hipocampo izquierdo en bebés prematuros.
- FC entre el precuneo izquierdo y el operculo de Rolandic izquierdo / putamen derecho correlacionado positivamente con las puntuaciones de NBNA.
Conclusiones:
- Los bebés prematuros pueden exhibir alteraciones tempranas de la conectividad funcional en el precuneus izquierdo.
- Estas deficiencias podrían ser un correlato neuronal de anomalías neuroconductuales.
- Los hallazgos ofrecen información sobre los mecanismos de neurodesarrollo relacionados con el nacimiento prematuro e informan la evaluación clínica temprana.
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