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Potencial anticancerígeno de las nanopartículas de selenio biogénico de levadura y bacterias lácticas: avances,
G M Rodríguez-Serrano1, M Párraga-San Roman2, C E Jara-Gutiérrez2
1Departamento de Biotecnología, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Ciudad de México AP 55-355, México.
Resumen
Las nanopartículas de selenio microbiano (SeNPs) son prometedoras para el tratamiento del cáncer debido a su síntesis ecológica y sus efectos anticancerígenos selectivos. Se necesita más investigación para estandarizar la producción y confirmar los beneficios terapéuticos.
Área de la Ciencia:
- La nanomedicina es la nanomedicina.
- Biotecnología La biotecnología es la biotecnología.
- Ciencia de los materiales Ciencia de los materiales.
Sus antecedentes:
- Las nanopartículas de selenio biogénicas microbianas (SeNPs) están surgiendo como herramientas valiosas en la nanomedicina.
- Su síntesis ecológica y sus propiedades anticancerígenas inherentes los hacen atractivos para el desarrollo terapéutico.
Objetivo del estudio:
- Para revisar la síntesis de SeNPs utilizando levadura y bacterias de ácido láctico.
- Explorar sus propiedades fisicoquímicas, mecanismos anticancerígenos y potencial terapéutico en el tratamiento del cáncer.
Principales métodos:
- Búsqueda sistemática de la literatura a través de las principales bases de datos científicas (PubMed, Scopus, Web of Science, ScienceDirect).
- Inclusión de estudios de 2010-2025 centrados en la síntesis microbiana de SeNP y aplicaciones biomédicas.
- Análisis temático de 108 artículos seleccionados que cubren síntesis, caracterización, mecanismos y aplicaciones.
Principales resultados:
- La levadura y las bacterias son agentes microbianos efectivos para la biosíntesis de SeNP, produciendo nanopartículas estables y biocompatibles.
- Las propiedades del SeNP como el tamaño y la forma influyen en la actividad biológica, induciendo la apoptosis de las células cancerosas y el daño del ADN.
- Los SeNP microbianos demuestran toxicidad selectiva hacia las células cancerosas con un impacto reducido en los tejidos sanos, y la funcionalización mejora su rendimiento terapéutico.
Conclusiones:
- Los SeNP microbianos son nanomateriales sostenibles con un potencial significativo en la investigación contra el cáncer.
- Los desafíos incluyen la ampliación de la producción, la estandarización de la síntesis y la realización de más evaluaciones clínicas.
Palabras clave:
Producción biogénica de nanopartículas.Metabolismo de las bacterias del ácido láctico.Metabolismo de las levaduras.El selenio es el selenio.Las nanopartículas de selenio.Los aminoácidos del selenio-selenio.Más Videos Relacionados
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