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Un enfoque pragmático para integrar la medicina basada en la evidencia y la medicina personalizada: el ejemplo de
D Zeilstra1,2, A A Te Velde3, G Remmers4
1Nutriz, Deventer, the Netherlands.
Beneficial microbes
|February 11, 2026
Resumen
La medicina personalizada basada en la evidencia (EBPM) integra la medicina basada en la evidencia (EBM) y la medicina personalizada (PM) para optimizar la atención al paciente. Este enfoque combina los datos de los pacientes con la clasificación de la evidencia para sugerencias de tratamiento a medida, mejorando la toma de decisiones clínicas.
Área de la Ciencia:
- La informática médica es la informática médica.
- Apoyo para la toma de decisiones clínicas.
- Práctica basada en la evidencia.
Sus antecedentes:
- Los profesionales de la salud buscan una atención óptima al paciente, pero definir la "mejor" intervención es complejo.
- La medicina basada en la evidencia (EBM) y la medicina personalizada (PM) ofrecen marcos para la selección de la intervención, cada uno con limitaciones.
- La integración de EBM y PM puede mejorar la toma de decisiones clínicas al aprovechar las fortalezas de ambos paradigmas.
Objetivo del estudio:
- Revisar las fortalezas y debilidades de EBM y PM desde la perspectiva del paciente y el HCP.
- Explorar los aspectos metodológicos y prácticos de la integración de EBM y PM.
- Proponer y ejemplificar un enfoque pragmático, la medicina personalizada basada en la evidencia (EBPM), para seleccionar las intervenciones óptimas.
Principales métodos:
- Revisión de la literatura sobre las fortalezas y debilidades de EBM y PM.
- Análisis epistemológico para integrar EBM y PM bajo una cosmovisión pragmática.
- Desarrollo y aplicación de un modelo EBPM de cuatro pasos para intervenciones dirigidas al microbioma.
Principales resultados:
- Un enfoque pragmático (EBPM) puede combinar las fortalezas de EBM y PM.
- El modelo EBPM integra datos individuales del paciente, sus preferencias y pruebas graduadas.
- El método EBPM propuesto facilita sugerencias de intervención personalizadas y circuitos de retroalimentación.
Conclusiones:
- La medicina personalizada basada en la evidencia (EBPM, por sus siglas en inglés) ofrece un marco sólido para optimizar la selección de intervenciones.
- El enfoque EBPM mejora la toma de decisiones clínicas mediante la personalización de recomendaciones basadas en la evidencia.
- Esta estrategia integrada es prometedora para mejorar los resultados de los pacientes a través de una atención médica personalizada.
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