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Biomarcadores inflamatorios periféricos asociados con la abstinencia del alcohol delirio en el trastorno por consumo
Metin Aslan1, Salih Cihat Paltun1, Mine Ergelen1
1Faculty of Medicine, Department of Psychiatry, Erenkoy Mental and Nervous Diseases Training and Research Hospital, Health Science University, Istanbul, Turkey.
The American journal of drug and alcohol abuse
|February 11, 2026
Resumen
El delirio por abstinencia de alcohol (AWD) está relacionado con elevados marcadores inflamatorios como la relación monocito-linfocito (MLR). Estos sencillos análisis de sangre pueden ayudar a identificar AWD y ayudar en la estratificación del riesgo del paciente.
Área de la Ciencia:
- La investigación médica es la investigación médica.
- El diagnóstico clínico es el diagnóstico clínico.
- Los biomarcadores de la inflamación
Sus antecedentes:
- El delirio de abstinencia alcohólica (AWD) es una complicación grave del trastorno por consumo de alcohol, asociada con una morbilidad y mortalidad significativas.
- La inflamación sistémica está implicada en la abstinencia severa del alcohol, pero la utilidad clínica de los biomarcadores inflamatorios periféricos sigue sin estar clara.
Objetivo del estudio:
- Para comparar los índices inflamatorios periféricos en pacientes con AWD, abstinencia de alcohol sin delirio (AWS) y controles sanos.
- Para determinar si estos índices pueden diferenciar AWD de AWS.
Principales métodos:
- Un estudio retrospectivo de 232 adultos (81 AWD, 91 AWS, 60 controles).
- Comparación de datos sociodemográficos, clínicos y de laboratorio en las 24 horas posteriores al ingreso.
- Utilizó análisis de características operativas del receptor (ROC) y regresión logística multivariable.
Principales resultados:
- La proporción de monocitos a linfocitos (MLR), la proporción de plaquetas a linfocitos (PLR) y la proporción de proteína C reactiva a albúmina (CAlb) fueron significativamente más altas en pacientes con AWD.
- La relación entre neutrófilos y linfocitos (NLR) se asoció de manera independiente con AWD (OR = 1.84) y proporcionó un valor pronóstico más allá de la historia y la gravedad.
- MLR mostró la mejor diferenciación entre AWD y AWS (AUC = 0.760), mientras que NLR mejor distinguió AWS de los controles (AUC = 0.796).
Conclusiones:
- Los índices inflamatorios periféricos simples, específicamente NLR y MLR, se asocian de manera independiente con AWD.
- Estos biomarcadores ofrecen utilidad diagnóstica para complementar la evaluación clínica para la estratificación del riesgo en pacientes con abstinencia del alcohol.
Palabras clave:
Trastorno por consumo de alcohol y trastorno por consumo de alcohol.Alkol Kullanım Bozukluğu es también conocido como Alkol Kullanım.Alkol yoksunluğu deliryumu deliryumu deliryumu deliryumu deliryumu deliryumu deliryumu deliryumu deliryumuBiobellirteçler fue un éxito.Nötrofil-Lenfosit Oranı también está disponible.Trombosit-Lenfosit Oranıı se encuentra en el mismo lugar.Alcohol abstinencia delirio delirio por abstinenciaLos biomarcadores también son biomarcadores.La inflamación es la inflamación de la inflamación.La proporción de neutrófilos y linfocitos.La proporción de plaquetas y linfocitos.La inflamación es la inflamación.Más Videos Relacionados
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