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Progreso de la enfermedad a largo plazo en la pancreatitis pediátrica aguda recurrente y crónica: un informe de
Elissa M Downs1, Emily R Perito2, Fuchenchu Wang3
1University of Minnesota, United States.
Resumen
Casi 1 de cada 5 niños con pancreatitis aguda recurrente (ARP) progresó a pancreatitis crónica (PC). Los factores de riesgo para la progresión a PC incluyen la genética y los episodios frecuentes de pancreatitis aguda.
Área de la Ciencia:
- Gastroenterología Pediátrica Gastroenterología pediátrica
- Pancreatología pancreatología.
Sus antecedentes:
- La pancreatitis aguda recurrente en la infancia (PRA) puede conducir a la pancreatitis crónica (PC).
- El grupo de estudio internacional de pancreatitis pediátrica: en busca de una cohorte cuRE (INSPPIRE) ofrece información sobre la progresión de la enfermedad.
Objetivo del estudio:
- Para analizar la progresión de la ARP a la parálisis cerebral en niños.
- Para identificar los factores de riesgo y secuelas asociadas con la progresión de la pancreatitis en una cohorte pediátrica.
Principales métodos:
- Categorizó a 626 niños en ARP persistente (pARP), CP incidente (iCP) o CP prevalente (pCP).
- Se analizaron el tiempo hasta la secuela y los factores de riesgo para la progresión utilizando datos recopilados prospectivamente.
Principales resultados:
- El 21,1% de los casos de ARP progresó a la PCI.
- Los casos de PC incidentes eran más propensos a tener mutaciones PRSS1, factores obstructivos y episodios de pancreatitis más agudos.
- La insuficiencia pancreática exocrina (EPI) se desarrolló en el 24% de los niños durante el seguimiento; el 32% de los casos de PCI interna desarrollaron EPI.
- La diabetes mellitus (DM) se desarrolló en el 8% durante el seguimiento.
Conclusiones:
- Casi uno de cada cinco niños con ARP progresó a PC.
- La genética, la enfermedad obstructiva y la alta frecuencia de episodios son factores de riesgo para la progresión.
- Un subconjunto de niños desarrolló secuelas irreversibles como EPI y DM.
Palabras clave:
Dolor abdominal y dolor en el abdomen.La pancreatitis aguda recurrente aguda y recurrente.La pancreatitis crónica es una pancreatitis crónica.La diabetes mellitus también se conoce como diabetes mellitus.Insuficiencia pancreática exócrina La insuficiencia pancreática exócrina es una insuficiencia pancreática exócrina.La pediatría es la medicina de los niños.
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