Video Experimental Relacionado
Updated: Feb 13, 2026
11:04
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
Published on: January 13, 2023
3.8K
Nanopartículas de coordinación cobre-verteporfina para revertir la resistencia a la ferroptosis en el tratamiento del
Zhen Jiang1, Jiadong Wang1, He Ren1
1School of Synthetic Biology and Biomanufacturing, State Key Laboratory of Synthetic Biology, Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300350, P.R. China. ymzhang88@tju.edu.cn.
Nanoscale
|February 11, 2026
Resumen
El cáncer de páncreas resiste la ferroposis debido al eje Xc-/SLC7A11 y YAP. Un nuevo nanosistema, CuVP-F127-IKE-Mem, se dirige a YAP e induce la ferroptosis, superando la resistencia e inhibiendo el crecimiento tumoral.
Área de la Ciencia:
- Ingeniería Biomédica Ingeniería Biomédica.
- Oncología Oncología.
- Biología Molecular Biología Molecular
Sus antecedentes:
- La ferroptosis, una muerte celular dependiente del hierro, es prometedora para la terapia del cáncer, pero se enfrenta a la resistencia en el cáncer de páncreas.
- Esta resistencia está relacionada con el eje Xc-/SLC7A11/GSH/GPX4 hiperactivado y la sobreexpresión SLC7A11 impulsada por YAP.
Objetivo del estudio:
- Desarrollar una nueva estrategia terapéutica para superar la resistencia a la ferroptosis en el cáncer de páncreas.
- Para investigar un enfoque de regulación transcripcional dirigido a YAP combinado con la inducción de ferroptosis.
Principales métodos:
- El cribado de las metaloporfirinas identificó la cobre-verteporfina (CuVP) como un inhibidor de la YAP.
- Desarrollo de un nanosistema dirigido a tumores (CuVP-F127-IKE-Mem) que integra el CuVP y la imidazol cetona erastina (IKE).
- Evaluación de la liberación sensible al pH del nanosistema, la inhibición de YAP/SLC7A11, la alteración de la homeostasis redox y la eficacia antitumoral en modelos de cáncer de páncreas.
Principales resultados:
- El nanosistema CuVP-F127-IKE-Mem suprimió efectivamente la actividad de YAP y desreguló la transcripción de SLC7A11.
- La acción dual de CuVP e IKE interrumpió sinérgicamente el eje de defensa Xc-/SLC7A11/GSH/GPX4, mejorando la sensibilidad a la ferroposis.
- Los estudios in vivo demostraron una inhibición significativa del crecimiento tumoral en modelos de cáncer de páncreas.
Conclusiones:
- La regulación transcripcional dirigida a YAP combinada con la inducción de ferroptosis es una estrategia potente contra el cáncer de páncreas.
- El nanosistema desarrollado ofrece un nuevo paradigma para superar la resistencia a la ferroptosis y tratar el cáncer de páncreas.
Videos de Conceptos Relacionados
02:49Cancer Therapies
10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
02:56Treatment Resistant Cancers
3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
02:57Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K
02:57Coordination Number and Geometry
19.1K
For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
19.1K
02:54Coordination Compounds and Nomenclature
26.9K
In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
26.9K
02:33Lattice Centering and Coordination Number
12.2K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
Types of Unit Cells
Imagine taking a large number of identical...
12.2K