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La administración antimicrobiana protocolizada después de la neumonía por filmarray más las pruebas de panel en
Sofía Cano1, Mª Ángeles Clari1, Eliseo Albert1
1Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
Scientific reports
|February 11, 2026
Resumen
El panel Biofire Filmarray neumonía más (FA-PP) mejoró la administración antimicrobiana en pacientes en estado crítico con infecciones del tracto respiratorio inferior. Esta herramienta de diagnóstico mejoró los ajustes antimicrobianos apropiados y redujo los días de tratamiento con antibióticos en general, demostrando ser rentable.
Área de la Ciencia:
- Enfermedades infecciosas Enfermedades infecciosas.
- Medicina de cuidados críticos Medicina de cuidados críticos.
- Microbiología Clínica y Microbiología Clínica.
Sus antecedentes:
- Las infecciones del tracto respiratorio inferior (ITRA) en pacientes con ventilación mecánica requieren una administración antimicrobiana efectiva.
- La terapia antimicrobiana empírica (TAE) es común, lo que requiere diagnósticos rápidos y precisos.
- Las pruebas microbiológicas convencionales tienen limitaciones en cuanto a velocidad y rendimiento para los patógenos LRTI.
Objetivo del estudio:
- Evaluar el impacto del panel Biofire Filmarray neumonía más (FA-PP) en el uso de antimicrobianos y la rentabilidad en pacientes con ventilación mecánica con LRTI.
- Para comparar el rendimiento diagnóstico y los resultados de administración de FA-PP frente a las pruebas microbiológicas estándar.
- Evaluar la oportunidad y la adecuación de los ajustes de la terapia antimicrobiana basados en los resultados de FA-PP.
Principales métodos:
- Estudio retrospectivo que compara los períodos de implementación antes y después de la FA-PP.
- La inclusión de 213 pacientes en estado crítico con IATR con ventilación mecánica, la mayoría en EAT.
- Análisis de los aspirados endotraqueales utilizando cultivos convencionales y FA-PP, centrándose en los ajustes antimicrobianos y la duración del tratamiento.
Principales resultados:
- FA-PP aumentó el rendimiento de detección de patógenos en comparación con el cultivo convencional.
- El ajuste apropiado de EAT se produjo con más frecuencia y más temprano después de la implementación de FA-PP.
- No hubo diferencias significativas en la duración total del tratamiento antimicrobiano entre los grupos, pero FA-PP permitió la reducción de los días de antibiótico con una relación costo-efectividad incremental favorable (€151/día).
Conclusiones:
- La administración antimicrobiana impulsada por los resultados de FA-PP es más rápida que la práctica estándar.
- FA-PP proporciona una adecuación comparable de la terapia antimicrobiana con un aumento insignificante en los costos.
- El panel FA-PP es una herramienta valiosa para optimizar el uso de antimicrobianos y mejorar la rentabilidad en pacientes en estado crítico con LRTI.
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