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El VHB reprograma el microambiente tumoral en el carcinoma hepatocelular: mecanismos e implicaciones terapéuticas
Xiaodong Shen1, Hechen Huang1, Jianpeng Sheng2
1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Clinical and experimental medicine
|February 11, 2026
Resumen
La infección por el virus de la hepatitis B (VHB) impulsa el cáncer de hígado (HCC) al alterar el microambiente tumoral (TME). Esta revisión explora los cambios en la EMT inducidos por el VHB y las terapias novedosas para mejores resultados en los pacientes.
Área de la Ciencia:
- Hepatología y Oncología.
- Inmunología y Biología del Cáncer.
Sus antecedentes:
- La infección por el virus de la hepatitis B (VHB) es una gran preocupación para la salud mundial.
- El VHB es un factor clave del carcinoma hepatocelular (CCH) a través de mecanismos oncogénicos.
- La infección por el VHB reprograma significativamente el microambiente tumoral (EMT).
Objetivo del estudio:
- Revisar los cambios multifacéticos en la EMT inducida por la infección por el VHB.
- Examinar los mecanismos de promoción tumoral y evasión inmune impulsados por el VHB.
- Discutir las estrategias terapéuticas emergentes para el CCH relacionado con el VHB.
Principales métodos:
- Revisión de la literatura de las alteraciones de EMT inducidas por el VHB.
- Análisis de la desregulación epigenética y la disfunción de las células inmunes.
- Examen de la fibrosis y la remodelación del estroma en el CCH relacionado con el VHB.
Principales resultados:
- La infección por el VHB conduce a la inmunosupresión y la adaptación metabólica dentro de la EMT.
- Los cambios epigenéticos y la disfunción de las células inmunes promueven el crecimiento tumoral.
- La fibrosis y la remodelación del estroma contribuyen a la progresión del CHC y a la evasión inmune.
Conclusiones:
- Comprender la reprogramación de la EMT inducida por el VHB es crucial para el tratamiento del CHC.
- Las terapias novedosas como el bloqueo del punto de control inmune y la orientación metabólica son prometedoras.
- Dirigirse a la EMT ofrece nuevas vías para mejorar los resultados de los pacientes con CHC relacionado con el VHB.
Palabras clave:
El virus de la hepatitis B (VHB) es elEl carcinoma hepatocelular (HCC, por sus siglas en inglés)La inmunoterapia es una inmunoterapia.El microambiente tumoral (EMT) es el microambiente del tumor.Más Videos Relacionados
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