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Amiloidosis pulmonar nodular localizada: un diagnóstico infrecuente con características similares a las de una
Mouna Zghal1, Sirine Jedda1, Hanen Bouattour2
1Department of Pathology and Research Laboratory LR18SP10, Habib Bourguiba University Hospital, University of Sfax, El Ain Road Km 0.5, 3029 Sfax, Tunisia.
Indian journal of thoracic and cardiovascular surgery
|February 12, 2026
Resumen
La amiloidosis pulmonar nodular (APN) es una rara afección pulmonar que se presenta como nódulos. La histopatología confirma el diagnóstico, crucial para diferenciarla del cáncer de pulmón y evitar cirugías innecesarias.
Área de la Ciencia:
- Neumología
- Patología
- Radiología
Sus antecedentes:
- Los nódulos pulmonares son hallazgos comunes en las imágenes torácicas.
- La neoplasia maligna es una preocupación principal en el diagnóstico diferencial de los nódulos pulmonares.
- La amiloidosis pulmonar nodular (APN) localizada es una causa extremadamente rara de nódulos pulmonares.
Objetivo del estudio:
- Presentar un caso de amiloidosis pulmonar nodular (APN) localizada.
- Destacar los desafíos diagnósticos y la importancia de la confirmación histopatológica.
- Enfatizar la necesidad de considerar la APN en el diagnóstico diferencial de los nódulos pulmonares.
Principales métodos:
- Presentación de un caso de una mujer de 83 años con un nódulo pulmonar descubierto incidentalmente.
- El estudio diagnóstico incluyó radiografía de tórax, tomografía computarizada (TC) y resección en cuña.
- El examen histopatológico con tinción de rojo Congo y microscopía de luz polarizada confirmó la deposición de amiloide.
Principales resultados:
- La TC de tórax reveló un nódulo periférico subpleural con márgenes espiculados, sospechoso de malignidad.
- La histología mostró depósitos amorfos acelulares compatibles con amiloide, sin lesiones neoplásicas.
- El estudio de amiloidosis sistémica fue negativo, confirmando la APN localizada.
Conclusiones:
- La amiloidosis pulmonar nodular (APN) localizada puede imitar el cáncer de pulmón radiológicamente.
- El diagnóstico definitivo se basa en el examen histopatológico.
- Considerar la APN en el diagnóstico diferencial previene el diagnóstico erróneo y los procedimientos quirúrgicos extensos innecesarios.
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