Video Experimental Relacionado
Updated: Feb 13, 2026

14:40
Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
Published on: October 27, 2020
20.1K
Comportamiento de mirada activa organiza la actividad de V1 en titíes en libre movimiento
bioRxiv : the preprint server for biology
|February 12, 2026
Resumen
La visión de los primates en la corteza visual primaria (V1) está activamente moldeada por el comportamiento natural de la mirada. Los movimientos oculares como los cambios de mirada y las fijaciones modulan la actividad neuronal, demostrando un vínculo entre la visión natural y las respuestas cerebrales.
Área de la Ciencia:
- Neurociencia
- Investigación sobre la visión de primates
Sus antecedentes:
- Los primates dependen en gran medida de la visión para la interacción con el medio ambiente.
- La mayoría de los estudios de la corteza visual de los primates utilizan modelos con la cabeza fija, lo que limita la comprensión de la visión activa natural.
Objetivo del estudio:
- Investigar cómo el sistema visual de los primates soporta la visión activa en animales en libre movimiento.
- Explorar la actividad neuronal en la corteza visual primaria (V1) durante el comportamiento natural de la mirada.
Principales métodos:
- Se utilizó un sistema de seguimiento ocular montado en la cabeza en titíes en libre movimiento.
- Se registró simultáneamente la actividad de conjuntos de neuronas individuales de V1.
Principales resultados:
- La actividad neuronal de los primates en V1 está estrechamente impulsada por la entrada visual y organizada por el comportamiento de la mirada.
- Las respuestas relacionadas con la mirada se abolieron sin entrada visual.
- Los cambios de mirada suprimieron las respuestas de V1, mientras que la fijación las mejoró, lo que se relacionó con la entrada visual.
Conclusiones:
- Se definieron las dinámicas de V1 que vinculan el comportamiento natural de la mirada y las respuestas impulsadas por estímulos en primates en libre movimiento.
- Se establecieron paradigmas en libre movimiento para estudiar el procesamiento visual del mundo real durante comportamientos etológicamente relevantes.
Videos de Conceptos Relacionados
Co-activators and Co-repressors
8.7K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.7K
Secondary Active Transport
138.2K
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
138.2K
tRNA Activation
23.1K
Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...
23.1K
Activation Energy
87.1K
Activation energy is the minimum amount of energy necessary for a chemical reaction to move forward. The higher the activation energy, the slower the rate of the reaction. However, adding heat to the reaction will increase the rate, since it causes molecules to move faster and increase the likelihood that molecules will collide. The collision and breaking of bonds represents the uphill phase of a reaction and generates the transition state. The transition state is an unstable high-energy state...
87.1K
Eukaryotic Transcription Activators
12.9K
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These...
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These...
12.9K
Prokaryotic Transcriptional Activators and Repressors
25.6K
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...
Transcription of prokaryotic...
25.6K

